SNRI and hyponatremia

Sand, Philipp; Atzinger, Armin; Buwe, A.

doi:10.1002/gps.601

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…This constellation is in accordance with four previous reports also showing the occurrence of hyponatremia during reboxetine treatment (Ranieri et al 2000;Schwartz and Veith 2000;Sand et al 2002;Abdelrahman et al 2003). In line with earlier studies, symptoms improved after the administration of sodium chloride, while no response to antipsychotic medication was observed (Brown et al 1983;Verghese et al 1998;Kawai et al 2002).…”

Section: Discussionsupporting

confidence: 94%

“…Drugs may trigger the inappropriate secretion of the antidiuretic hormone, also known as vasopressin, and may thus lead to severe side effects, e.g., seizures and coma (e.g., Siegel et al 1998). Compared to SSRIs and SNRIs there are only few data available on hyponatremia following treatment with NaRIs (Ranieri et al 2000;Sand et al 2002;Abdelrahman et al 2003), some of them provided by reports to the manufacturing company (Schwartz and Veith 2000). These cases comprise observations of SIADH-induced hyponatremia in reboxetinemedicated elderly patients.…”

Section: Introductionmentioning

confidence: 97%

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A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine

Koelkebeck

Domschke

Zwanzger

et al. 2009

The World Journal of Biological Psychiatry

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Hyponatremia is a well-known side effect of antidepressant treatment with serotonin reuptake inhibitors (SSRI) or combined serotonin and noradrenaline reuptake inhibitors (SNRI), and is linked to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in most cases. In contrast, only very few data are available on hyponatremia following treatment with selective noradrenaline reuptake inhibitors (NaRI). In this report, we describe the case of a patient who developed severe hyponatremia after treatment with reboxetine. However, extensive laboratory testing did not reveal inappropriate secretion of ADH, suggesting that SIADH did not account for hyponatremia in our case. Proposing further examination of the underlying pathomechanism of hyponatremia as a side effect of NaRIs, we discuss the importance of careful monitoring of serum sodium levels in patients treated with NaRIs.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 97%

A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine

Koelkebeck

Domschke

Zwanzger

et al. 2009

The World Journal of Biological Psychiatry

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“…Antidepressant-related hyponatremia by way of SIADH has been reported for all classes of antidepressants such as tricyclic antidepressants, 7 selective serotonin reuptake inhibitors, 5 serotonin-norepinephrine reuptake inhibitors, 8 and monoamine oxidase inhibitor. 9 Syndrome of inappropriate secretion of antidiuretic hormone associated with psychotropic medications is related to increased hypothalamic production of antidiuretic hormone.…”

Section: Discussionmentioning

confidence: 99%

Possible Association of Syndrome of Inappropriate Secretion of Antidiuretic Hormone With St John’s Wort Use

Jones

Tourian²,

Margolese³

2014

Journal of Clinical Psychopharmacology

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“…However, an adequate interpretation of the level of ADH can be made only when it is compared with the simultaneously measured serum osmolality, its secretion being normally stopped when serum osmolality falls below 280 mosmol L (1 [22]. Clinical experience shows that almost all antidepressants have been implicated in the production of the syndrome of inappropriate antidiuretic hormone (SIADH) [17], including the newer mirtazapine [23], reboxetine [24], and duloxetine [25]. The usual management of hyponatraemia due to drug-induced SIADH is to stop the offending antidepressant and wait, or to institute fluid restriction as well.…”

mentioning

confidence: 99%