Social Cognition and Visual Perception in Schizophrenia Inpatients Treated with First-and Second-Generation Antipsychotic Drugs

Kucharska-Pietura, Katarzyna; Mortimer, Ann; Tylec, Aneta; Czernikiewicz, Andrzej

doi:10.3371/csrp.6.1.2

Cited by 15 publications

(11 citation statements)

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“…Finally, Kucharska-Pietura et al [35] assessed deficits in social cognitive functioning in a naturalistic pragmatic sample of partially remitted stable schizophrenia inpatients, 28 being treated with a FGA (perphenazine or haloperidol), 56 being treated with a SGA (olanzapine or clozapine), and 50 healthy controls. In line with previous findings, there were no differences between the patient groups in emotional perception and ToM/empathy.…”

Section: Does Antipsychotic Treatment Improve Social Cognition?mentioning

confidence: 99%

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Can Antipsychotics Improve Social Cognition in Patients with Schizophrenia?

Kucharska-Pietura

Mortimer

2013

CNS Drugs

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Social cognition is described as the higher mental processes that are engaged while people store, process, and use social information to make sense of themselves and others. Aspects of social cognition include emotion perception, social cue interpretation, attribution style, and theory of mind, all of which appear disordered in schizophrenia. Such social cognitive deficits are believed to be important predictors of functional outcome in schizophrenia, therefore they may represent a crucial treatment target. Few studies have evaluated the influence of antipsychotic treatment on these deficits. The purpose of this review is to examine the relationship between antipsychotic treatment and social cognition, whether antipsychotics improve social cognitive function, and if so to explore differential medication effects. Comprehensive searches of PsycINFO and MEDLINE/PUBMED were conducted to identify relevant published manuscripts. Fifteen relevant papers published in English were found, describing original studies. On the basis of this review, we have drawn the following conclusions: first, the results do not engender optimism for the possibility that antipsychotic drugs can specifically facilitate social recovery. Second, the actions of antipsychotics on social cognition are inconclusive, due to lack of standardization across research groups, leading to inconsistencies between study designs, methods used, and medication dosages. Third, large-scale longitudinal investigations are needed to explore the unclear relationships between social cognition, symptoms, and functional outcome. Other non-pharmacological treatments focusing on training patients in the social cognitive areas may hold more promise.

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Section: Does Antipsychotic Treatment Improve Social Cognition?mentioning

confidence: 99%

“…This is particularly striking given the supposedly superior effects of clozapine previously reported. There were small but significant advantages for SGAs in non-social low-level visual processing: this was thought to result from SGAs’ weaker antagonism of dopamine receptors in the retina [35]. …”

Section: Does Antipsychotic Treatment Improve Social Cognition?mentioning

confidence: 99%

Can Antipsychotics Improve Social Cognition in Patients with Schizophrenia?

Kucharska-Pietura

Mortimer

2013

CNS Drugs

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“…Social cognition has been defined as the mental operations underlying social interactions, and is thought to represent a specialised domain of cognition, which captures affect perception, social cue perception, “theory of mind”, empathy, and attribution style [18]. As far as facial affect recognition is concerned, robust research data seemed to report less accuracy of AN patients at recognising basic facial emotions [7, 16, 21, 33].…”

Section: Introductionmentioning

confidence: 99%

Intact social cognitive processes in outpatients with anorexia nervosa: a pilot study

Kucharska

Jeschke

Mafi³

2016

Ann Gen Psychiatry

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ObjectiveThe aim of the study was to assess social cognition in community patients suffering from anorexia nervosa (AN) compared to healthy controls.Methods25 women diagnosed with AN and 25 women matched for education level and age were involved in the study. Both subject groups were assessed using a set of validated experimental tasks, such as the facial expression recognition test, short recognition memory test for faces, ‘Reading the mind in the eyes’ test. Patients were assessed for symptoms of: eating disorder (the eating attitudes test—EAT-26), OCD (the Yale–Brown obsessive compulsive scale—Y-BOCS) and depression (Beck depression inventory—BDI). The research hypothesis indicated that patients suffering from anorexia represent no significant difference in social cognitive functioning in comparison to the healthy controls. These assessment scales were used to identify whether there are any problems according to social cognitive functioning especially emotion recognition and theory of mind (ToM). The primary outcome assessment was to identify social cognitive deficits in anorexic outpatients and secondary outcome was to verify whether these problems in emotional functioning found in women in acute phase of AN are state or trait effects.ResultsAnorexic patients showed significantly higher scores on EAT-26, BDI and Y-BOCS. No significant differences were found in performance of social cognitive tests and facial perception test.DiscussionNo marked alterations were found in social cognitive functioning in community patients with average body mass index (BMI) of 17.6. This may indicate that social cognition is a very complex construct to be reliably measured in anorexia nervosa considering relatively limited psychometric data for many social cognitive tasks. Further longitudinal studies are needed to untangle ongoing controversy whether social cognitive deficits in AN could be state or trait related.

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“…From our PubMed search of more recent studies not included in the meta-analyses, a total of 16 of the 20 studies that examined adults with chronic schizophrenia either did not report on sex differences or controlled for sex in their FEP analyses [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] , with one study including an all-male sample [68] . Of the remaining four studies, three studies did not find sex differences on an FEP identification task [69][70][71] . By contrast, Erol et al [72] found sex differences in FEP: Chronically ill women with schizophrenia performed equivalently to men and women without schizophrenia on both identification and discrimination FEP tasks, while men with schizophrenia performed worse on both tasks.…”

Section: Adults With Chronic Schizophreniamentioning

confidence: 99%

Facial emotion perception in schizophrenia: Does sex matter?

Mote

Kring

2016

WJP

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AIM:To review the literature on sex differences in facial emotion perception (FEP) across the schizophrenia spectrum. METHODS:We conducted a systematic review of empirical articles that were included in five separate meta-analyses of FEP across the schizophrenia spectrum, including meta-analyses that predominantly examined adults with chronic schizophrenia, people with early (onset prior to age 18) or recent-onset (experiencing their first or second psychotic episode or illness duration less than 2 years) schizophrenia, and unaffected first-degree relatives of people with schizophrenia. We also examined articles written in English (from November 2011 through June 2015) that were not included in the aforementioned metaanalyses through a literature search in the PubMed database. All relevant articles were accessed in full text. We examined all studies to determine the sample sizes, diagnostic characteristics, demographic information, methodologies, results, and whether each individual study reported on sex differences. The results from the meta-analyses themselves as well as the individual studies are reported in tables and text. RESULTS:We retrieved 134 articles included in five separate meta-analyses and the PubMed database that examined FEP across the schizophrenia spectrum. Of these articles, 38 examined sex differences in FEP. Thirty of these studies did not find sex differences in FEP in either chronically ill adults with schizophrenia, early-onset or recently diagnosed people with schizophrenia, or first-degree relatives of people with schizophrenia. Of the eight studies that found sex differences in FEP, three found that chronically ill women outperformed men, one study found that girls with early-onset schizophrenia outperformed boys, and two studies found that women (including first-degree relatives, adults with schizophrenia, and the healthy control group) outperformed men on FEP tasks. In total, six of the eight studies that examined sex differences in FEP found that women outperformed men across the SYSTEMATIC REVIEWS Core tip: People with schizophrenia exhibit deficits in facial emotion perception (FEP) compared to healthy controls. These deficits are associated with poorer functioning and more severe symptoms. Although the literature to date suggests that there are few sex differences in FEP in schizophrenia, continued assessment of sex differences in FEP can help researchers and clinicians better understand other sex differences in the disorder and assist in treatment development aimed at improving functioning in people with schizophrenia. This review summarizes and critically evaluates the literature on FEP across the schizophrenia spectrum, focusing on the evidence related to sex differences in FEP.Mote J, Kring AM. Facial emotion perception in schizophrenia: Does sex matter? World J Psychiatr 2016; 6(2): 257-268

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Social Cognition and Visual Perception in Schizophrenia Inpatients Treated with First-and Second-Generation Antipsychotic Drugs

Abstract: We cannot conclude that SGAs were associated with better social cognition than FGAs. However, there were small but significant advantages for SGAs in non-social visual processing function, as evaluated with the VOSP.

Cited by 15 publications

References 28 publications

Can Antipsychotics Improve Social Cognition in Patients with Schizophrenia?

Can Antipsychotics Improve Social Cognition in Patients with Schizophrenia?

Intact social cognitive processes in outpatients with anorexia nervosa: a pilot study

Facial emotion perception in schizophrenia: Does sex matter?

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