Social instability is an effective chronic stress paradigm for both male and female mice

Yohn, Christine N.; Ashamalla, Sandra A.; Bokka, Leshya; Gergues, Mark M.; Garino, Alexander; Samuels, Benjamin Adam

doi:10.1016/j.neuropharm.2019.107780

Cited by 55 publications

(51 citation statements)

References 69 publications

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“…It would be interesting if aspects of sexual maturation and male fertility would be further verified in this model. More recently, one study reported that a slight modification to the chronic social instability protocol (every 3 days for 7 weeks) was effective for inducing pro-anxiety and depressive-like behaviours in adult male mice 40 , so intergenerational modifications could be further investigated in that model. While it is unknown whether different intergenerational outcomes are dependent on the age at which CORT treatment commences (juvenile vs adult), such a comparison would be challenging due to the established differences in the physical adaptative responses to chronic low-dose CORT treatment by adolescent (4 weeks of age) and adult (10 weeks of age) mice 29 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

Fennell

Busby

et al. 2020

Sci Rep

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Independent studies have observed that a paternal history of stress or trauma is associated with his children having a greater likelihood of developing psychopathologies such as anxiety disorders. This father-to-child effect is reproduced in several mouse models of stress, which have been crucial in developing a greater understanding of intergenerational epigenetic inheritance. We previously reported that treatment of C57Bl/6J male breeders with low-dose corticosterone (CORT) for 28 days prior to mating yielded increased anxiety-related behaviours in their male F1 offspring. The present study aimed to determine whether subchronic 7-day CORT treatment of male mice just prior to mating would be sufficient to induce intergenerational modifications of anxiety-related behaviours in offspring. We report that subchronic CORT treatment of male breeders reduced their week-on-week body weight gain and altered NR3C1 and CRH gene expression in the hypothalamus. There were no effects on sperm count and glucocorticoid receptor protein levels within the epididymal tissue of male breeders. Regarding the F1 offspring, screening for anxiety-related behaviours using the elevated-plus maze, light–dark box, and novelty-suppressed feeding test revealed no differences between the offspring of CORT-treated breeders compared to controls. Thus, it is crucial that future studies take into consideration the duration of exposure when assessing the intergenerational impacts of paternal health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

Fennell

Busby

et al. 2020

Sci Rep

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“…Vaginal lavage was conducted as previously described 34 , 35 , in order to determine which stage of the estrous cycle each female was in during test sessions (Supplemental Fig. 1 ).…”

Section: Methodsmentioning

confidence: 99%

Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice

2021

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Reward and motivation deficits are prominent symptoms in many mood disorders, including depression. Similar reward and effort-related choice behavioral tasks can be used to study aspects of motivation in both rodents and humans. Chronic stress can precipitate mood disorders in humans and maladaptive reward and motivation behaviors in male rodents. However, while depression is more prevalent in women, there is relatively little known about whether chronic stress elicits maladaptive behaviors in female rodents in effort-related motivated tasks and whether there are any behavioral sex differences. Chronic nondiscriminatory social defeat stress (CNSDS) is a variation of chronic social defeat stress that is effective in both male and female mice. We hypothesized that CNSDS would reduce effort-related motivated and reward behaviors, including reducing sensitivity to a devalued outcome, reducing breakpoint in progressive ratio, and shifting effort-related choice behavior. Separate cohorts of adult male and female C57BL/6 J mice were divided into Control or CNSDS groups, exposed to the 10-day CNSDS paradigm, and then trained and tested in instrumental reward or effort-related behaviors. CNSDS reduced motivation to lever press in progressive ratio and shifted effort-related choice behavior from a high reward to a more easily attainable low reward in both sexes. CNSDS caused more nuanced impairments in outcome devaluation. Taken together, CNSDS induces maladaptive shifts in effort-related choice and reduces motivated lever pressing in both sexes.

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“…Rodents that undergo this paradigm exhibit an anxiety and depressive like phenotype in open field, EPM and social interaction tests, and elevated peripheral corticosterone level [ 127 , 128 , 129 ] and lower hypothalamic glucocorticoid receptor (GR) expression [ 129 ]. The depressive-like behavior induced by the social instability paradigm is reversed by chronic antidepressant treatment with fluoxetine in both males and females [ 257 ]. This model mimics the male chronic social defeat stress model in many aspects, except for the gender differences and fewer ethical concerns.…”

Section: Models Of Depressionmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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Social instability is an effective chronic stress paradigm for both male and female mice

Cited by 55 publications

References 69 publications

Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice

Animal Models of Depression: What Can They Teach Us about the Human Disease?

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