Social Selection in the Cellular Slime Moulds

Nanjundiah, Vidyanand; Sathe, Santosh

doi:10.1007/978-3-642-38487-5_11

Cited by 5 publications

(3 citation statements)

References 120 publications

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“…Another important issue that could be addressed in future modeling efforts refers to the role of stochastic fluctuations among genetically homogeneous cells. This has indeed been reported as a relevant factor in the determination of cell types in some multicellular organisms formed by aggregation (Nanjundiah and Sathe, 2013 ).…”

Section: Discussionmentioning

confidence: 55%

Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach

et al. 2015

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Multicellularity has emerged and continues to emerge in a variety of lineages and under diverse environmental conditions. In order to attain individuality and integration, multicellular organisms must exhibit spatial cell differentiation, which in turn allows cell aggregates to robustly generate traits and behaviors at the multicellular level. Nevertheless, the mechanisms that may lead to the development of cellular differentiation and patterning in emerging multicellular organisms remain unclear. We briefly review two conceptual frameworks that have addressed this issue: the cooperation-defection framework and the dynamical patterning modules (DPMs) framework. Then, situating ourselves in the DPM formalism first put forward by S. A. Newman and collaborators, we state a hypothesis for cell differentiation and arrangement in cellular masses of emerging multicellular organisms. Our hypothesis is based on the role of the generic cell-to-cell communication and adhesion patterning mechanisms, which are two fundamental mechanisms for the evolution of multicellularity, and whose molecules seem to be well-conserved in extant multicellular organisms and their unicellular relatives. We review some fundamental ideas underlying this hypothesis and contrast them with empirical and theoretical evidence currently available. Next, we use a mathematical model to illustrate how the mechanisms and assumptions considered in the hypothesis we postulate may render stereotypical arrangements of differentiated cells in an emerging cellular aggregate and may contribute to the variation and recreation of multicellular phenotypes. Finally, we discuss the potential implications of our approach and compare them to those entailed by the cooperation-defection framework in the study of cell differentiation in the transition to multicellularity.

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Section: Discussionmentioning

confidence: 55%

Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach

et al. 2015

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“…In particular, they can provide clues about generic aspects of cell-fate determination in the transition to multicellularity (Arias Del Angel et al, 2016; Duran-Nebreda, Montañez, Bonforti, & Solé, 2016;Furusawa & Kaneko, 2002;Mora Van Cauwelaert, Del Angel, Antonio, Benítez, & Azpeitia, 2015). However, much less is known about the dynamic properties underlying cell-fate determination in the development of cellular aggregates, such as the fruiting bodies of Dictyostelium discoideum (Marée & Hogeweg, 2001;Nanjundiah & Sathe, 2013) and myxobacteria (Bretl & Kirby, 2016;Kroos, 2017). However, much less is known about the dynamic properties underlying cell-fate determination in the development of cellular aggregates, such as the fruiting bodies of Dictyostelium discoideum (Marée & Hogeweg, 2001;Nanjundiah & Sathe, 2013) and myxobacteria (Bretl & Kirby, 2016;Kroos, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Implementation of dynamic models for the study of cellular differentiation has been mostly limited to eukaryotic model organisms developing through a zygotic or "staying-together" mechanism (Albert & Othmer, 2003;Benítez et al, 2008;Jaeger & Reinitz, 2012). However, much less is known about the dynamic properties underlying cell-fate determination in the development of cellular aggregates, such as the fruiting bodies of Dictyostelium discoideum (Marée & Hogeweg, 2001;Nanjundiah & Sathe, 2013) and myxobacteria (Bretl & Kirby, 2016;Kroos, 2017).…”

Section: Introductionmentioning

confidence: 99%

Cell‐fate determination in Myxococcus xanthus development: Network dynamics and novel predictions

et al. 2018

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Myxococcus xanthus is a myxobacterium that exhibits aggregation and cellular differentiation during the formation of fruiting bodies. Therefore, it has become a valuable model system to study the transition to multicellularity via cell aggregation. Although there is a vast set of experimental information for the development on M. xanthus, the dynamics behind cell-fate determination in this organism's development remain unclear. We integrate the currently available evidence in a mathematical network model that allows to test the set of molecular elements and regulatory interactions that are sufficient to account for the specification of the cell types that are observed in fruiting body formation. Besides providing a dynamic mechanism for cell-fate determination in the transition to multicellular aggregates of M. xanthus, this model enables the postulation of specific mechanisms behind some experimental observations for which no explanations have been provided, as well as new regulatory interactions that can be experimentally tested. Finally, this model constitutes a formal basis on which the continuously emerging data for this system can be integrated and interpreted.

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Complex interactions underpin social behaviour in Dictyostelium giganteum

Sathe

Nanjundiah

2018

Behav Ecol Sociobiol

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Social Selection in the Cellular Slime Moulds

Cited by 5 publications

References 120 publications

Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach

Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach

Cell‐fate determination in Myxococcus xanthus development: Network dynamics and novel predictions

Complex interactions underpin social behaviour in Dictyostelium giganteum

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