Social support and outcomes in older adults with lung cancer

Chambers, Andrew G.; Damone, Emily; Chen, Yi Tang; Nyrop, Kirsten A.; Deal, Allison M.; Muss, Hyman B.; Charlot, Marjory

doi:10.1016/j.jgo.2021.09.009

Cited by 14 publications

(12 citation statements)

References 30 publications

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“…In addition to an association between emotional support and HRQoL, the current study suggests that inadequate emotional support is associated with depression. These findings are congruent with several prior studies suggesting that patients with depression scored lower on measures of social or emotional support 9,37,38 . Interestingly, one prospective study followed patients with cancer of all ages with baseline depression and anxiety for 12 months and found that those with better social support had greater improvements in their mental health condition compared to those with lower social support 9 .…”

Section: Discussionsupporting

confidence: 87%

“…Second, >80% of patients reported adequate emotional support for each question, meaning that the frequency of inadequate emotional support was somewhat low. This is, however, consistent with previous studies, but limits the ability to determine the specific source of emotional support deficiencies among older patients with cancer 37 . Third, HRQoL and emotional support were measured at one point in time, so we are unable to establish causality.…”

Section: Discussionsupporting

confidence: 66%

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Association of emotional support with quality of life, mental health, and survival in older adults with gastrointestinal malignancies–Results from the CARE registry

Clausing,

Fowler,

Harmon

et al. 2023

Cancer Medicine

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BackgroundEmotional support (ES) is the most frequently reported support need among older adults with cancer. Yet, the association of ES with cancer outcomes is largely unknown. This study examined the association of ES with health‐related quality of life (HRQoL), mental health, and survival among older adults with gastrointestinal (GI) malignancies.MethodsWe included newly diagnosed older adults (≥60 years) with GI cancer undergoing self‐reported geriatric assessment at their first clinic visit. ES was measured using an adaptation of the Medical Outcomes Study (dichotomized adequate ES vs. inadequate ES). Outcomes included physical and mental HRQoL, anxiety, depression, and survival. Multivariable linear regression evaluated the association between ES and HRQoL scores. Multivariable logistic regression evaluated the association of ES with anxiety and depression. All models were adjusted for age at geriatric assessments, race, sex, and cancer type/stage.Results795 participants were included. Median patient age was 68 years (IQR: 64–74), 58% were male, and most cancers were either colorectal (37.9%) or pancreatic (30.8%). Most (77.6%) had adequate ES. Patients with inadequate ES were more likely to be Black (31.5 vs. 20.8%, p = 0.005), disabled (24.1 vs. 10.4%, p < 0.001), widowed/divorced (54.2 vs. 24.8%, p < 0.001) and had lower physical and mental HRQoL t‐scores (Physical β: −3.35, 95% CI: −5.25, −1.46; Mental β: ‐2.46, 95% CI: −4.11, −0.81) and higher odds of depression (aOR: 2.22, CI: 1.34–3.69). This study found no difference between those with adequate ES versus inadequate ES in the proportion of deaths within 1 year of diagnosis (24.3% vs. 24.2%, p = 0.966), or within 2 years of diagnosis (32.4% vs. 33.2%, p = 0.126).ConclusionsOlder adults with inadequate ES have worse physical and mental HRQoL and higher odds of depression compared to those with adequate ES.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 66%

Association of emotional support with quality of life, mental health, and survival in older adults with gastrointestinal malignancies–Results from the CARE registry

Clausing,

Fowler,

Harmon

et al. 2023

Cancer Medicine

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“…36 Studies in patients with chronic illnesses have demonstrated a connection between increased caregiver burden and a poor support network with worse patient quality of life and outcomes. [37][38][39][40][41][42][43] The results of this study highlight opportunities to improve the well-being of caregivers of patients with PDAC receiving NT. Unfortunately, there is a lack of practical tools for screening caregivers and identifying how to best support them.…”

Section: Impact Frequency Representative Quotementioning

confidence: 84%

Evaluating the caregiver experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma

Ruff,

Stevens,

Bressler

et al. 2023

Journal of Surgical Oncology

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IntroductionNeoadjuvant therapy (NT) is increasingly recommended for patients with localized pancreatic ductal adenocarcinoma (PDAC). Recent research has highlighted the significant treatment burden that patients experience during NT, but caregiver well‐being during NT is poorly understood.MethodsA cross‐sectional mixed‐methods analysis of primary caregivers of patients with localized PDAC receiving NT was undertaken. All patients completed the Caregiver Quality of Life Index‐Cancer (CQOLC) survey, while semi‐structured interviews were conducted among a convenience sample of participants.ResultsAmong 28 caregivers, the mean age was 60.1 years, and most were patient spouses/significant others (71.4%). Patients had resectable (18%), borderline resectable (46%), or locally advanced (36%) PDAC with a mean treatment duration of 2.9 months at the time of their caregiver's enrollment. Most caregivers felt that they received adequate emotional/psychosocial support (80%) and understood the rationale for NT (93%). A majority (60%) reported that caregiving responsibilities impacted their daily lives and required a decrease in their work hours, leading to financial challenges (47%). While overall QOL was moderate (mean 83 ± 21.1, range 0–140), “emotional burden” (47.3 ± 20.9), and “positive adaption” (57.3 ± 13.9) were the lowest ranked CQOLC subsection scores.DiscussionCaregivers of patients with PDAC undergoing NT experience significant emotional symptoms and impact on their daily lives. Assessing caregiver needs and providing resources during NT should be a priority.

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“…In the layer of interpersonal networks, social support was a predictor of the risk of early CRC recurrence. Andrew et al 42 discovered that social support could influence clinical outcomes in lung cancer patients, which may be related to potential molecular mechanisms by which social support influences cancer progression. Patients with cancer who have a wider social network and higher levels of social support tend to have better survival rates 43,44 , and high levels of social support play a significant role in improving the prognosis of patients with cancer.…”

Section: Discussionmentioning

confidence: 99%

Predictive models based on machine learning for early recurrence and metastasis in postoperative patients with colorectal cancer

Dong,

Mo,

Huang

et al. 2024

Interdisciplinary Nursing Research

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Objectives: To construct and validate a prediction model based on machine learning algorithms for early recurrence and metastasis in patients with colorectal cancer after surgery. Methods: This study employed a prospective cohort design. A total of 498 postoperative patients with colorectal cancer, treated at an affiliated hospital of Qingdao University, were recruited using convenience sampling from June to December 2021. Data were collected during outpatient visits and hospitalizations. The risk factors for early recurrence and metastasis of colorectal cancer were determined through multivariate logistic regression analysis in SPSS 26.0 software. Using Python 3.7.0 software, four machine learning algorithms (logistic regression, Support Vector Machine, XGBoost, and LightGBM) were used to develop and validate prediction models for early recurrence and metastasis of colorectal cancer after surgery. Results: Of the 498 patients, 51 (10.24%) had early recurrence and metastasis. Multivariate logistic regression analysis showed that personal traits (family history of cancer, histological type, degree of tumor differentiation, number of positive lymph nodes, and T stage), behaviour and/or lifestyle (intake of refined grains, whole grains, fish, shrimp, crab, and nuts, as well as resilience), and interpersonal networks (social support) were all associated with early recurrence and metastasis of colorectal cancer (P<0.05). The logistic regression prediction model showed the best prediction performance out of the four models, with an accuracy rate of 0.920, specificity of 0.982, F1 of 0.495, AUC of 0.867, Kappa of 0.056, and Brier score of 0.067. Conclusion: Our findings suggest that a prediction model based on logistic regression could accurately and scientifically predict which patients are likely to experience early recurrence and metastasis, helping to lessen the burden for both patients and the healthcare system.

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Social support and outcomes in older adults with lung cancer

Cited by 14 publications

References 30 publications

Association of emotional support with quality of life, mental health, and survival in older adults with gastrointestinal malignancies–Results from the CARE registry

Association of emotional support with quality of life, mental health, and survival in older adults with gastrointestinal malignancies–Results from the CARE registry

Evaluating the caregiver experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma

Predictive models based on machine learning for early recurrence and metastasis in postoperative patients with colorectal cancer

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