Socio-environmental conditions and geographical variability of asthma prevalence in Northeast Brazil

Franco, Jackeline; Gurgel, Ricardo Queiróz; Solé, Dírceu; França, Vera Lúcia Alves; Brabin, Bernard

doi:10.1016/s0301-0546(09)71722-7

Cited by 21 publications

(19 citation statements)

References 23 publications

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“…In addition, FICZ also interferes with Th2 differentiation, likely by inhibiting activation of STAT-6 and expression of GATA3. The results presented in this study support epidemiological studies and animal studies that UV radiation may help protect against asthma [29][30][31]37,54], although the relationship between the prevalence of asthma and geographical latitude is still controversial: both positive [54,55] and negative associations [56,57] between them have been reported in the published literature. So far, most studies about effects of AhR ligands on the immune system have been performed with environmental contaminants such as TCDD, which is rarely metabolized.…”

Section: Discussionsupporting

confidence: 84%

FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

Jeong

Hwang

et al. 2012

International Immunopharmacology

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Section: Discussionsupporting

confidence: 84%

FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

Jeong

Hwang

et al. 2012

International Immunopharmacology

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“…Franco et al [1] showed a statistically significant positive correlation between geographical latitude and active asthma prevalence in the eight International Study of Asthma and Allergies in Childhood (ISAAC) centres in North-East Brazil. The authors found no relation between the tropical weather and high prevalence of childhood asthma in the studied population.…”

Section: Discussionmentioning

confidence: 99%

“…Both positive [1], [2] and negative associations [3], [4] between the prevalence of asthma/allergies and geographical latitude have been reported in the published literature. This is an ecological study designed to test the proposed hypothesis that the prevalence of asthma increases with increasing latitude due to a decreasing intensity of solar irradiation which effectively reduces the individual's cutaneous generation of vitamin D.…”

Section: Introductionmentioning

confidence: 92%

Asthma Prevalence Associated with Geographical Latitude and Regional Insolation in the United States of America and Australia

Krstić

2011

PLoS ONE

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BackgroundIt has been proposed that vitamin D deficiency may be responsible for an increase in the prevalence of allergic diseases and asthma worldwide. Human ability to generate physiologically required quantities of vitamin D through sun exposure is decreasing with increasing geographical latitude.ObjectivesConsidering that vitamin D deficiency is usually due to lack of outdoor sun exposure, this study is designed to test the hypothesis that a higher prevalence of asthma should be expected at high relative to low geographical latitudes.MethodsLinear regression analyses are performed on asthma prevalence in the U.S. adult population vs. geographical latitude, insolation, air temperature, and air pollution (PM2.5) for 97 major metropolitan/micropolitan statistical areas of the continental United States of America and on general population asthma prevalence vs. geographical latitude in eight metropolitan areas of Australia.ResultsA 10° change in geographical latitude from southern to northern regions of the Eastern Seaboard is associated with a 2% increase in adult asthma prevalence (p<0.001). Total insolation in winter months is almost as strong as latitude in its ability to explain the observed spatial variation in the prevalence of asthma (r2 = 0.43; p<0.001). Similar results are obtained using the Australian data (r2 = 0.73; p<0.01), suggesting a consistent association between the latitude/insolation and asthma prevalence worldwide.ConclusionsThe results of this study suggest that, as a known modulator of the immune response closely linked with the geographical latitude and erythemal UV irradiation, vitamin D may play an important role in the development/exacerbation of asthma.

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“…Therefore if vitamin D is truly important in asthmatic disease we can expect higher asthma incidence at higher latitude. Indeed, several reports have suggested that latitude is positively correlated to asthma [2,56,87,95] and allergy [80]. However, not all ecological studies demonstrate this effect, with some studies noting no interaction [81,114], and others still an increased risk at lower latitude [131,151,170,176,187].…”

Section: Epidemiologic Datamentioning

confidence: 99%

Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies

Kerley

Elnazir

Faul

et al. 2015

Pulmonary Pharmacology & Therapeutics

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. Emerging evidence suggests that VDD is associated with increased airway hyperresponsiveness, decreased pulmonary function, worse asthma control, and possibly decreased response to standard antiasthma therapy. However the effect is inconsistent with preliminary evidence from different studies suggesting vitamin D is both beneficial and detrimental to asthma genesis and severity.Current evidence suggests that supplementation with moderate doses of vitamin D may be appropriate for maintenance of bone health in asthmatics, particularly steroid users. However emerging data from an increasing number of randomized, controlled, intervention studies of vitamin D supplementation in pediatric and adult asthma are becoming available and should help determine the importance, if any of vitamin D for asthma pathogenesis.The purpose of this second of a two-part review is to review the current human literature on vitamin D and asthma, discussing the possible consequences of VDD for asthma and the potential for vitamin D repletion as adjunct therapy.

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Socio-environmental conditions and geographical variability of asthma prevalence in Northeast Brazil

Abstract: Relation between the tropical weather and high prevalence of asthma was not confirmed. There were associations with water privation and latitude.

Cited by 21 publications

References 23 publications

FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

Asthma Prevalence Associated with Geographical Latitude and Regional Insolation in the United States of America and Australia

Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies

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