SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model

Mesaki, Kumi; Yamane, Masaomi; Sugimoto, Seiichiro; Fujisawa, Masayoshi; Yoshimura, Teizo; Kurosaki, T.; Otani, Shinji; Miyoshi, Shinichiro; Oto, Takahiro; Matsukawa, Akihiro; Toyooka, Shinichi

doi:10.1007/s00595-018-1753-5

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…The activation of the TLR7/8 signaling pathway led to the activation of NF-κB which was required for the induction of TNF-α [17]. SOCS3, as a suppressor of cytokine signaling, has been implicated in transcriptional activation of signal transduction and activators of transcription (STAT) signaling pathway [18][19][20]. SOCS3 is up-regulated in response to various cytokines such as TNF-α, IL-6 and growth hormone [21].…”

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data

et al. 2020

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Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases. The present study aimed to identify hub genes involved in the pathogenesis and further explore the potential treatment targets of RA and OA. Methods: The gene expression profile of GSE12021 was downloaded from Gene Expression Omnibus (GEO). Total 31 samples (12 RA, 10 OA and 9 NC samples) were used. The differentially expressed genes (DEGs) in RA versus NC, OA versus NC and RA versus OA groups were screened using limma package. We also verified the DEGs in GSE55235 and GSE100786. Functional annotation and protein–protein interaction (PPI) network construction of OA- and RA-specific DEGs were performed. Finally, the candidate small molecules as potential drugs to treat RA and OA were predicted in CMap database. Results: 165 up-regulated and 163 down-regulated DEGs between RA and NC samples, 73 up-regulated and 293 down-regulated DEGs between OA and NC samples, 92 up-regulated and 98 down-regulated DEGs between RA and OA samples were identified. Immune response and TNF signaling pathway were significantly enriched pathways for RA- and OA-specific DEGs, respectively. The hub genes were mainly associated with ‘Primary immunodeficiency’ (RA vs. NC group), ‘Ribosome’ (OA vs. NC group), and ‘Chemokine signaling pathway’ (RA vs. OA group). Arecoline and Cefamandole were the most promising small molecule to reverse the RA and OA gene expression. Conclusion: Our findings suggest new insights into the underlying pathogenesis of RA and OA, which may improve the diagnosis and treatment of these intractable chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data

et al. 2020

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“…In pristane-induced lupus mice, injection of tofacitinib, a Janus kinase (JAK) 1/JAK3 inhibitor, significantly inhibited the expression of suppressor of cytokine signaling (SOCS) 1 but upregulated the expression of SOCS3 ( 27 ). SOCS3 transgenic mice showed alleviation of airway obstruction and epithelial loss as compared with those in control mice, along with reduced expression of T-bet in lungs of the mice ( 28 ). OT-I CD8 + T cells cultured with H2-Kb (SIINFEKL) complex and IL-2 induced ectopic T-bet expression and led to reduced expression of SOCS1 ( 29 ).…”

Section: Transcription Factor T-betmentioning

confidence: 99%

Th1-related transcription factors and cytokines in systemic lupus erythematosus

Tang,

Wang,

Chen

et al. 2023

Front. Immunol.

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Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been widely discussed in autoimmunity, such as SLE. In this review, we will comprehensively discuss the expression profile of the Th1 cell family in both SLE patients and animal models and clarify how the family members are involved in lupus development. Interestingly, T-bet-related age-associated B cells (ABCs) and low-dose IL-2 treatment in lupus were emergently discussed as well. Collection of the evidence will better understand the roles of the Th1 cell family in lupus pathogenesis, especially targeting IL-2 in lupus.

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“…As evidenced by these studies, cytokines are important modulators of T-cell responses in transplantation outside of their typical functions in activation and differentiation, and targeting one or a few of these pathways can alter transplant outcomes. Significantly, Mesaki et al [29] provide evidence that the overexpression of suppressor of cytokine signaling three (SOCS3) in T cells results in reduced epithelial damage and obstruction of murine tracheal allografts. Combined, these studies suggest that altering cytokine signaling in T cells in transplantation represents a promising avenue of research to improve transplant outcome, even beyond the typical roles of cytokines in altering Tcell activation and differentiation.…”

Section: Cytokine Signaling On T Cellsmentioning

confidence: 99%

When rubber meets the road: how innate features of adaptive immune cells play critical roles in transplant alloimmunity

Morris

Ford²

2019

Current Opinion in Organ Transplantation

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Purpose of reviewStudies on adaptive cells have largely focused on features that are specific to adaptive immunity. However, adaptive cells utilize innate cell features to modulate their responses, and this area of T and B-cell biology is understudied. This review will highlight recent work done to understand how innate features of adaptive immune cells modulate alloimmunity. Recent findingsOver the past year, research has shown that T-cell-expressed danger-associated molecular patterns, Toll-like receptors, complement receptors, and Fc receptors regulate T-cell alloimmunity in a cell-intrinsic manner. Further, IL-17 and p40 of IL-12 have been implicated in the migration of T cells into allografts. Lastly, innate B cells, specifically B1 cells, have been shown to produce clinically relevant autoantibody associated with poor graft outcome.

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SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model

Cited by 5 publications

References 41 publications

Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data

Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data

Th1-related transcription factors and cytokines in systemic lupus erythematosus

When rubber meets the road: how innate features of adaptive immune cells play critical roles in transplant alloimmunity

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