2010
DOI: 10.1016/j.nbd.2010.04.008
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SOD1 mRNA expression in sporadic amyotrophic lateral sclerosis

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Cited by 62 publications
(65 citation statements)
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References 30 publications
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“…These reports have been confirmed by others looking at expression profile of several genes in ALS (64). Conversely, others have suggested that SOD1 expression might be higher in ALS patients (11,19). This duplicity regarding SOD1 expression in ALS is confusing, and it is mostly likely confounded by the complex pathology of the disease, or attributable to disease-associated mutations in SOD1.…”
Section: Als-associated Changes In Expressionmentioning
confidence: 86%
“…These reports have been confirmed by others looking at expression profile of several genes in ALS (64). Conversely, others have suggested that SOD1 expression might be higher in ALS patients (11,19). This duplicity regarding SOD1 expression in ALS is confusing, and it is mostly likely confounded by the complex pathology of the disease, or attributable to disease-associated mutations in SOD1.…”
Section: Als-associated Changes In Expressionmentioning
confidence: 86%
“…Regulatory mechanisms normally preventing toxicity of WT SOD1 at basal expression levels might be unable to operate in conditions of overexpression. In line with this possibility, neuronal tissue abnormalities have been reported in WT SOD1 transgenic mice [19], and abnormally high levels of SOD1 transcripts were reported in spinal cord, brain stem and lymphocytes of sporadic ALS patients [20], although it remains to be investigated whether these conditions are associated to overstimulation of Rac1-mediated pathway for lamellipodia.…”
Section: Discussionmentioning
confidence: 99%
“…SOD1 mRNA levels are also elevated in sporadic ALS, so the role of SOD1 in the motor neuron disease is not limited to the familial cases [108]. The SOD1 mutation toxicity is linked to proteasome function [109] and changes metabolism [110].…”
Section: The Relationship To Als: Evolution Of Aging and Neurologicalmentioning
confidence: 99%