“…The endothelium is a semipermeable membrane that regulates hydration by providing a barrier to the leakage of fluid into the stroma and by active ion transport across endothelial membranes. 1,[9][10][11][12][13][14][15][16] The fluid transport across the endothelium is believed to be mediated by multiple distinct pumps, one involving Na + /K + adenosine triphosphatase and another, carbonic anhydrase. A sodium ion concentration gradient is established by basolaterally located Na + /K + ATPase.…”