Sodium Channel β Subunits: Emerging Targets in Channelopathies

O’Malley, Heather A.; Isom, Lori L.

doi:10.1146/annurev-physiol-021014-071846

Cited by 218 publications

(272 citation statements)

References 158 publications

(269 reference statements)

Supporting

Mentioning

255

Contrasting

Unclassified

Order By: Relevance

“…A recent review drew attention to the possible pharmacological manipulation of b subunits of Na + channels rather than the pore-forming a subunits (O'Malley and Isom, 2015). This approach may be especially attractive as three different types of b subunits are differentially and selectively expressed in small, medium, and large DRG neurons (Zhao et al, 2011;Ho et al, 2012).…”

Section: Role Of Ectopic Activity In Primary Afferent Fibersmentioning

confidence: 99%

Etiology and Pharmacology of Neuropathic Pain

Alles¹,

Smith²

2018

Pharmacol Rev

311

251

View full text Add to dashboard Cite

Section: Role Of Ectopic Activity In Primary Afferent Fibersmentioning

confidence: 99%

Etiology and Pharmacology of Neuropathic Pain

Alles¹,

Smith²

2018

Pharmacol Rev

311

251

View full text Add to dashboard Cite

“…2B) (Ahern et al, 2016). The biophysical properties of alpha subunits, as well as their trafficking, are regulated by the interacting VGSC beta subunits, which comprise 4 genes and 5 members, as one of them presents two splicing variants (O'Malley and Isom, 2015). Among the latter, the predominant beta subunit expressed in pancreatic beta cells is Scn1b (Ernst et al, 2009;Zhang et al, 2014).…”

Section: Ion Channel Modulation In Beta Cellsmentioning

confidence: 99%

Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells

et al. 2016

View full text Add to dashboard Cite

Pancreatic beta cells, unique cells that secrete insulin in response to an increase in glucose levels, play a significant role in glucose homeostasis. Glucose-stimulated insulin secretion (GSIS) in pancreatic beta cells has been extensively explored. In this mechanism, glucose enters the cells and subsequently the metabolic cycle. During this process, the ATP/ADP ratio increases, leading to ATP-sensitive potassium (K ATP ) channel closure, which initiates depolarization that is also dependent on the activity of TRP nonselective ion channels. Depolarization leads to the opening of voltage-gated Na 1 channels (Nav) and subsequently voltage-dependent Ca 21 channels (Cav).The increase in intracellular Ca 21 triggers the exocytosis of insulin-containing vesicles. Thus, electrical activity of pancreatic beta cells plays a central role in GSIS. Moreover, many growth factors, incretins, neurotransmitters, and hormones can modulate GSIS, and the channels that participate in GSIS are highly regulated. In this review, we focus on the principal ionic channels (K ATP , Nav, and Cav channels) involved in GSIS and how classic and new proteins, hormones, and drugs regulate it. Moreover, we also discuss advances on how metabolic disorders such as metabolic syndrome and diabetes mellitus change channel activity leading to changes in insulin secretion.

show abstract

“…Also, the β subunits are expressed in various cell/tissue types, including heart, skeletal muscle, PNS, CNS, adrenal gland and kidney (50). It has been reported that mutations in β subunits are associated with several diseases, such as epilepsy, cardiac arrhythmia, and sudden death syndromes (51). The VGSC β subunits serve as therapeutic targets, therefore, development of selective drugs targeting these accessory subunits would be beneficial.…”

Section: Voltage-gated Sodium Channelmentioning

confidence: 99%

A Short Guide to Electrophysiology and Ion Channels

Rubaiy

2017

J Pharm Pharm Sci

View full text Add to dashboard Cite

ABSTRACT:The birth and discovery of electrophysiological science took place in the 18 th century laying the path for our understanding of nerve membrane ionic currents. The pore-forming proteins, ion channels, are involved and play critical roles in very important physiological and pathological processes, such as neuronal signaling and cardiac excitability, therefore, they serve as therapeutic drug targets. The study of physiological, pharmacological and biophysical properties of ion channels can be done by patch clamp, a gold standard and powerful electrophysiological technique. The current review, in addition to highlight and cover the history of electrophysiology, patch clamp (conventional and automated) technique, and different types of ion channels, will also discuss the importance of ion channels in different neurological diseases and disorders. As the field of neuroscience is growing, this manuscript is intended as a guide to help in understanding the importance of ion channels, particularly in neuroscience, and also in using the patch clamp technique for the study of molecular physiology, pathophysiology, and pharmacology of neuronal ion channels. Importantly, this review will spotlight on the therapeutic aspect of neuronal ion channels.

show abstract

Sodium Channel β Subunits: Emerging Targets in Channelopathies

Cited by 218 publications

References 158 publications

Etiology and Pharmacology of Neuropathic Pain

Etiology and Pharmacology of Neuropathic Pain

Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells

A Short Guide to Electrophysiology and Ion Channels

Contact Info

Product

Resources

About