Sodium hydrogen sulfate as a catalyst for the synthesis of N,4-diaryl-6-methyl-1-methyl(phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides via the Biginelli reaction

The applications of β‐keto amides for heterocycle synthesis

“…CeCl 3 ‐catalyzed the synthesis of 420 , which are monastrol (a kinesin Eg5 inhibitor) analogues and potential anticancer agents [184]. Other methods such as TMSCl/DMF 421 procedure [185], solid‐phase protocol 422 [186], NaHSO 4 ‐catalyzed [187], Yb(OTf) 3 ‐catalyzed or FeCl 3 ‐catalyzed 423 synthesis were also developed (Scheme 105) [188].…”

Biginelli Reaction Mediated Synthesis of Antimicrobial Pyrimidine Derivatives and Their Therapeutic Properties

“…Further methods include using various catalysts, such as Bronsted acids, including H 3 BO 3 [ 15 ], HCOOH [ 21 ], p-TsOH-H 2 O [ 23 , 24 ], imidazole-1–yl-acetic acid [ 25 ], and L-(+)-tartaric acid-dimethylurea [ 26 ]; or Lewis acids, including LiClO 4 , Lal 3 , InCl 3 , BiCl 3 , Bi(OTf) 3 , Mn(OAc) 3 , Cu(OTf) 2 , CuCl 2 , FeCl 3 , ZrCl 4 , SnCl 2 , [ 27 , 28 , 29 , 30 , 31 , 32 ], Sr(OTf) 2 [ 33 ], VCl 3 [ 34 ], TaBr 5 [ 35 ], Ce(NO 3 ) 3 ·6H 2 O [ 36 ], ZrO 2 /SO 4 2− [ 37 ], silica-chloride (SiO 2 -Cl) [ 38 ], Sm(ClO 4 ) 3 [ 39 ], Y(NO 3 ) 3 ·6H 2 O [ 40 ], CeCl 3· 7H 2 O [ 41 ], Ce(NH 4 ) 2 (NO 3 ) 6 (CAN) [ 42 ], Fe(OTs) 3· 6H 2 O [ 43 ], Ca(HSO 4 ) 2 , Zn(HSO 4 ) 2 [ 44 ], SnCl 2 /nano SiO 2 [ 45 ], Cu(OAc) 2 [ 46 ], copper zirconium phosphate Cu(OH) 2 Zr(HPO 4 ) 2 [ 47 ], Sc(OTf) 3 , Yb(OTf) 3 , and Zn(OTf) 2 [ 48 ]. Other catalysts of the Biginelli reaction reported in the literature include co-phthalocyanines [ 49 ], NaHSO 4 [ 50 ], zeolites [ 51 , 52 ], clays [ 53 , 54 , 55 ], organic polymers [ 56 …”