Sodium Intake, Salt Taste and Gastric Cancer Risk According to Helicobacter Pylori Infection, Smoking, Histological Type and Tumor Site in China

Chen, Zhong; Li, Kainan; Bi, Jian; Wang, Baocheng

doi:10.7314/apjcp.2012.13.6.2481

Cited by 48 publications

(33 citation statements)

References 7 publications

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“…The mechanism by which H. pylori induces stomach cancer potentially involves chronic inflammation or the action virulence factors such as CagA (4). Dietary factors including some foods with high sodium such as smoked foods, salted fish and pickled vegetables are associated with higher risk (5). Smoking increases the risk of developing gastric cancer significantly (6).…”

Section: Introductionmentioning

confidence: 99%

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

et al. 2014

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Abstract. MCM7 (mini-chromosome maintenance protein 7) is essential for the initiation of genomic replication as a component of the pre-replication complex. The present study aimed to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma (GAC). The MCM7 protein was upregulated in all 9 GAC cell lines. In 6 paired primary GACs, MCM7 was upregulated in tumor compared with the corresponding non-tumorous gastric tissues. In normal gastric epithelium tissue, MCM7 was strictly expressed in the proliferative compartment. MCM7 knockdown by siRNA in gastric cancer cell line AGS and NCI-N87 significantly suppressed cell proliferation, inhibited monolayer colony formation, reduced cell invasion and induced late apoptosis. Its nuclear expression correlated with advanced age and poorer disease specific survival in diffuse-type GACs. All the findings supported that MCM7 might play an oncogenic role in gastric tumorigenesis. It serves as a potential prognostic marker and therapeutic target in diffuse-type GACs.

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Section: Introductionmentioning

confidence: 99%

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

et al. 2014

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“…Developing countries are at highest risk, due to people living in poor socioeconomic conditions. The increasing risk factor includes; poor sanitary conditions, overpopulation, consumption of raw foods, like food items purchased from street stalls and unsafe water supply sources (Zhong et al, 2012). Smoking and smokeless tobacco use are associated with increasing risk of H. pylori, which is very common in south Asian countries, mainly Pakistan (Wu et al, 2003;Valliani et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Helicobacter Pylori Infection, Results from a Developing Country-Pakistan

Valliani

Khan²,

Chagani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: It is known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. Infections due to H. pylori are most widespread among the developing regions due to poor standard of public health. This study sought to determine the association of H. pylori with ABO blood groups, age, gender, and smoking status among inpatients at a public sector hospital in Karachi. Materials and Methods: A cross-sectional study was conducted at endoscopy suite at a public sector hospital in Karachi in the year 2011. All the symptomatic patients coming for upper GIT endoscopy were included in this study. Results: Biopsy for histopathology was taken from 93 patients, with an age range from 15-65 years. Age group of 15 to 20 years was found to be associated with H. pylori infection but without significance (p-value 0.83). In all, 36 (38.7%) turned out to be H. pylori positive with a significant male preponderance (p=0.04). Distribution of ABO blood groups in H. pylori positive group were A=31.4%, B=15.4%, AB=25.0% and O=53.7%, with a statistically significant link for blood group O (p=0.05) . Rhesus factor was also compared but significant relationship was evident (p-value 0.73). Conclusions: This study demonstrated that H. pylori infection can be related to ABO blood group, middle age persons and male gender. People of blood group O are more prone to develop infection related gastritis, ulcers, and even perforations, so they should be more cautious against transmission of the bacterium.

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“…Most cancers share similar causes. Smoking, for instance, is not only linked with lung cancer, but also colorectal (Cross et al, 2014), gastric (Zhong et al, 2014), and breast cancer (Ilic et al, 2014). Therefore, smoking cessation prevents all these cancers at the same time.…”

Section: Discussionmentioning

confidence: 99%

Refining and Validating a Two-stage and Web-based Cancer Risk Assessment Tool for Village Doctors in China

Shen¹,

Chai²,

Feng³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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The big gap between efficacy of population level prevention and expectations due to heterogeneity and complexity of cancer etiologic factors calls for selective yet personalized interventions based on effective risk assessment. This paper documents our research protocol aimed at refining and validating a two-stage and webbased cancer risk assessment tool, from a tentative one in use by an ongoing project, capable of identifying individuals at elevated risk for one or more types of the 80% leading cancers in rural China with adequate sensitivity and specificity and featuring low cost, easy application and cultural and technical sensitivity for farmers and village doctors. The protocol adopted a modified population-based case control design using 72, 000 non-patients as controls, 2, 200 cancer patients as cases, and another 600 patients as cases for external validation. Factors taken into account comprised 8 domains including diet and nutrition, risk behaviors, family history, precancerous diseases, related medical procedures, exposure to environment hazards, mood and feelings, physical activities and anthropologic and biologic factors. Modeling stresses explored various methodologies like empirical analysis, logistic regression, neuro-network analysis, decision theory and both internal and external validation using concordance statistics, predictive values, etc..

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Sodium Intake, Salt Taste and Gastric Cancer Risk According to Helicobacter Pylori Infection, Smoking, Histological Type and Tumor Site in China

Cited by 48 publications

References 7 publications

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

Factors Associated with Helicobacter Pylori Infection, Results from a Developing Country-Pakistan

Refining and Validating a Two-stage and Web-based Cancer Risk Assessment Tool for Village Doctors in China

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