Sodium Nitroprusside, Pregnancy and Multiple Intracranial Aneurysms

Abstract

Where subarachnoid haemorrhage in pregnancy is caused by rupture of an intracranial aneurysm, surgery is considered to be the treatment of choice, offering the best results for both mother and foetus. 1.2,3 CASE REPORT A 23-year-old, 65-kilogram primipara of 16 weeks' gestation presented with a generalised headache of sudden onset, vomiting and photophobia. Investigations revealed two aneurysms-one basilar, the other on the left middle cerebral artery. Epsilon amino caproic acid was given over the three days preceding surgery. With no evidence of cerebrovascular spasm and preoperative blood pressure in the range of 100/40 to 130/70 mmHg, planned clipping of both aneurysms was undertaken on the eleventh day after admission. At operation, a third aneurysm was found, small and thinwalled, anslllg from the left carotid bifurcation. All three aneurysms were clipped. Arterial blood pressure (BP) via a radial artery cannula, end-tidal carbon dioxide, arterial gas analysis (AGA) and body temperature were monitored. Blood sugar

Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles

“…NO is involved in a myriad of processes in humans, including modulation of blood pressure and flow, tubular organ compliance, platelet aggregation, cell defense, memory, and blood vessel angiogenesis, among others. In bacteria, NO has been associated with the regulation of biofilm formation, quorum sensing, and also counter-defense to host. , Consequently, the therapeutic potential of NO donor molecules has bloomed with many exciting products in use and others under development. − Indeed, there are many old and new applications for NO donors such as antiparasitic, antihypertensive, anti-inflammatory pain, glaucoma, − asthma, arthritis, sexual impotence, bacterial biofilm disruption, , wound healing, , and anti-COVID-19, among many others. − Besides that, some companies (e.g., Bellerophon, Vero Biotech, BeyondAir) have also developed devices to generate NO in situ , which might be useful for certain conditions, despite that they still bear limitations of dosing, cost, and discomfort on their use.…”