In laboratory experiments with resting and germinated seeds of spring wheat, the effect of various biological preparations on the activity of catalase isoforms was studied. In the experiments, the activity of catalase isoforms was determined at pH = 5.5, 7.0, 8.0 using a phosphate buffer system (1/15 M phosphate buffer). The activity of catalase enzyme isoforms was determined in dormant wheat grain that underwent post-harvest ripening and during germination on the third, fifth, and seventh days using a method based on determining the amount of hydrogen peroxide dissolved under the action of the enzyme, and subsequent titration of the remaining undissolved hydrogen peroxide with potassium permanganate. In experiments, the effect of the following biopreparations protective and stimulating complex (PSC), Hardy, Ferovit and Ferovit+Hardy mixture, which were applied by foliar treatment during cultivation of wheat plants, was investigated. It has been established that changes in the activity of catalase isoforms occur both in dormant and germinating plant seeds and differ depending on the biological preparation used in plant cultivation.