Sofosbuvir and its tri-phosphate metabolite inhibit the RNA-dependent RNA polymerase activity of non-structural protein 5 from the Kyasanur forest disease virus

Malik, Mansi; Vijayan, Parvathy; Jagannath, Deepak K; Mishra, Rakesh; Lakshminarasimhan, Anirudha

doi:10.1016/j.bbrc.2022.12.023

Biochemical and Biophysical Research Communications

2023

DOI: 10.1016/j.bbrc.2022.12.023

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Sofosbuvir and its tri-phosphate metabolite inhibit the RNA-dependent RNA polymerase activity of non-structural protein 5 from the Kyasanur forest disease virus

Mansi Malik

Parvathy Vijayan

Deepak K Jagannath

et al.

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2024

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Kyasanur Forest Disease: A Comprehensive Review

Kandi,

et al. 2024

Cureus

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Vector-borne microbial diseases are ubiquitous, and their management remains elusive. Such diseases with zoonotic potential result in public health challenges requiring additional control and preventive measures. Despite their cosmopolitan presence, vector-borne infections are neglected due to their endemicity in specified geographical regions. The Kyasanur forest disease (KFD) caused by the Kyasanur forest disease virus (KFDV) is among such diseases transmitted through ticks and localized to India. Despite its prevalence, high transmissibility, and potential to cause fatalities, KFDV has not been given the deserved attention by the governments. Further, KFDV circulates in the rural and wild geographical areas threatening infections to people living in these areas with limited access to medical and healthcare. Therefore, physicians, healthcare workers, and the general population need to understand the KFDV and its ecology, epidemiology, transmission, pathogenesis, laboratory diagnosis, and control and prevention as described comprehensively in this review.

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Kyasanur Forest Disease: A Comprehensive Review

Kandi,

et al. 2024

Cureus

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Sofosbuvir and its tri-phosphate metabolite inhibit the RNA-dependent RNA polymerase activity of non-structural protein 5 from the Kyasanur forest disease virus

Cited by 1 publication

References 45 publications

Kyasanur Forest Disease: A Comprehensive Review

Kyasanur Forest Disease: A Comprehensive Review

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