Sofosbuvir induced leucocytoclasic vasculitis: a case report

Abstract

Background We describe a case of leucocytoclasic vasculitis induced by Sofosbuvir and its disappearence after the end of the therapy. The hepatitis C virus, firstly described in 1989, is a major global health problem, with high morbidity and mortality. We observed a temporal relationship between the treatment and the onset of vasculitis. We emphasize the multidisciplinary approach to the patients with liver disease to improve the quality of life of these patients. Case presentation A 53-year-old Caucasian man with a history of hepatitis C virus genotype 1 infection was examined at our Department of Dermatology for the occurrence of palpable purpura. The patient referred that the first appearance of the dermatoses was about one month after initiation of therapy with Sofosbuvir for hepatitis C. Conclusions Vasculitis appeared after the beginning of Sofosbuvir and, even though it was treated with different medications proved to be effective, it disappeared only after the conclusion of the therapy, giving a strong evidence to be a drug eruption.

A rapid favorable outcome after sofosbuvir induced leucocytoclastic vasculitis.

“…In this case, symptoms appeared one month after the beginning of the treatment. Skin lesions disappeared one month after the drug withdrawal (11). In our case, the patient recovered rapidly in only 2 days after stopping sofosbuvir without any symptomatic treatment.…”

Eczematous Drug Eruption Induced by Sofosbuvir/Velpatasvir: The Need for a Better Classification

“…Little is known about second-generation DAAs skin AEs because clinical trials do not differentiate between types of skin “rashes” and the causes for drug discontinuation. 1 Isolated cases of leucocytoclasic vasculitis, 8 pityriasis rubra pilaris-like drug eruption, 9 Steven-Johnson Syndrome, 10 hand–foot syndrome, 11 erythema multiforme, 12 and photoinduced drug eruption 13,14 have been reported with sofosbuvir, alone or in combination with other DAAs.…”