2019
DOI: 10.1590/s1678-9946201961012
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Sofosbuvir, ribavirin and pegylated interferon for a daclatasvir-resistent genotype 3 hepatitis C virus: case report and review

Abstract: Chronic Hepatitis C relapse after liver transplantation can lead to graft failure within a short time period. The high efficacy and good safety profile of direct-acting antivirals has led to consensual recommendations for using interferon-free treatment after liver transplantation. However, pegylated interferon may still be required for genotype 3 non-responders. We treated a liver graft recipient with grade 1 fibrosis in the biopsy with daclatasvir and sofosbuvir for 12 weeks. He did not respond and progresse… Show more

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Cited by 4 publications
(2 citation statements)
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“…Ribavirin discovered in the 1970s is one of the most remarkable nucleoside antivirals due to its antiviral activities, both in tissue culture and animal models against a uniquely broad range of viruses including DNA and RNA viruses [ 17 ] ( Figure 4 ). Ribavirin [ 18 ] is an approved drug against hepatitis C infection in combination with interferons alpha or in combination with other medications such as sofosbuvir [ 54 , 55 ]. Ribavirin has also been used for the treatment of other viral infections [ 56 , 57 ].…”
Section: Broad-spectrum Antiviral Nucleoside Analoguesmentioning
confidence: 99%
“…Ribavirin discovered in the 1970s is one of the most remarkable nucleoside antivirals due to its antiviral activities, both in tissue culture and animal models against a uniquely broad range of viruses including DNA and RNA viruses [ 17 ] ( Figure 4 ). Ribavirin [ 18 ] is an approved drug against hepatitis C infection in combination with interferons alpha or in combination with other medications such as sofosbuvir [ 54 , 55 ]. Ribavirin has also been used for the treatment of other viral infections [ 56 , 57 ].…”
Section: Broad-spectrum Antiviral Nucleoside Analoguesmentioning
confidence: 99%
“…For instance, telaprevir (an inhibitor of the HCV NS3/4 protease) in combination with PegIFN-␣/ribavirin can be effective in treating chronic HCV patients who are unresponsive to conventional PegIFN-␣/ribavirin therapy (55). Several other HCV NS3/4A protease inhibitors used in combination with PegIFN-␣ and ribavirin may also achieve improved rates of a sustained virological response (56)(57)(58)(59). However, the toxicity when they are combined with PegIFN-␣ and ribavirin still limits their overall efficacy (60,61).…”
Section: Fda-approved Host-directed Antiviral Agentsmentioning
confidence: 99%