Soft apoptotic-cell-inspired nanoparticles persistently bind to macrophage membranes and promote anti-inflammatory and pro-healing effects

Zhang, Guanglin; Xue, Haoyu; Sun, Dazheng; Yang, Shenyu; Zeng, Rong

doi:10.1016/j.actbio.2021.07.002

Cited by 29 publications

(12 citation statements)

References 45 publications

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“…[ 74–76 ] The stagnation of inflammation from early to the late stage is also characterized by the stalled transition of neutrophils to macrophages, leading to the persistence of inflammation and blocked wound healing. [ 77,78 ]…”

Section: Polarization Of Macrophages In Ordinary and Chronic Non‐heal...mentioning

confidence: 99%

“…[74][75][76] The stagnation of inflammation from early to the late stage is also characterized by the stalled transition of neutrophils to macrophages, leading to the persistence of inflammation and blocked wound healing. [77,78] Of all the cells involved in wound healing, macrophages are a prerequisite for the entire tissue repair, which are polarized at different healing stages and present different dynamic changes in phenotype and function. [79] Apart from their early recognition function in host defense and removal of apoptotic cell debris, macrophages play an important role in tissue development, homeostasis, and repair.…”

Section: Macrophage Polarization Of Chronic Non-healing Woundsmentioning

confidence: 99%

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Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Mao

Chen

Cai

et al. 2021

Adv Funct Materials

120

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Macrophage immunotherapy is an emerging treatment strategy that modulates the immune system to promote wound healing. The functionality and regeneration of tissue depend on spatially and temporally regulating the biophysical and biochemical microenvironmental with poorly understood mechanisms. Biomaterials are carefully crafted to display and deliver macrophage regulatory signals in a precise and near‐physiological way, serving as powerful artificial microenvironments in which to explore and direct the fate of macrophages. The review starts with discussing the classification and function of macrophages, and then introduces the polarization of macrophages in different microenvironments of conventional wounds and chronic wounds. Recent advances in biomaterials that balance the phenotypes of macrophages in wound healing are emphasized. Finally, looking ahead, the potential ability of biomaterial scaffolds to modulate immune signaling to produce an environment conducive to regeneration is discussed.

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Section: Polarization Of Macrophages In Ordinary and Chronic Non‐heal...mentioning

confidence: 99%

Section: Macrophage Polarization Of Chronic Non-healing Woundsmentioning

confidence: 99%

Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Mao

Chen

Cai

et al. 2021

Adv Funct Materials

120

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“…Interestingly, the maximum number of liposomes that could be endocytosed per cell as determined from the first order kinetic model was lower for the PEG-coated liposomes by a factor of 1.5. A recent report by Zhang et al using RAW 264.7 macrophages on the other hand indicates zero-order uptake kinetics of liposomes by these macrophages, suggesting effects of liposome composition, coating, and cell line . Magentoliposome (ML) in vitro kinetics were studied and framed within a mathematical model by Slabu et al Pancreatic tumor cell uptake kinetics were compared with healthy fibroblast cells.…”

Section: Uptake and Release Kinetics Of Nanoparticles In Vitromentioning

confidence: 99%

“…A recent report by Zhang et al using RAW 264.7 macrophages on the other hand indicates zero-order uptake kinetics of liposomes by these macrophages, suggesting effects of liposome composition, coating, and cell line. 101 Magentoliposome (ML) in vitro kinetics were studied and framed within a mathematical model by Slabu et al 102 Pancreatic tumor cell uptake kinetics were compared with healthy fibroblast cells. MiaPaCa-2 pancreatic tumor cells internalized three times more ML than BxPC-3 (another pancreatic tumor cell line) and L929 murine fibroblast cells.…”

Section: Uptake and Release Kinetics Of Nanoparticles In Vitromentioning

confidence: 99%

Integration of In Vitro and In Vivo Models to Predict Cellular and Tissue Dosimetry of Nanomaterials Using Physiologically Based Pharmacokinetic Modeling

et al. 2022

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Nanomaterials (NMs) have been increasingly used in a number of areas, including consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation of safety, efficacy, and potential toxicity of NMs. Current evaluation of NM efficacy and safety involves the time-consuming collection of pharmacokinetic and toxicity data in animals and is usually completed one material at a time. This traditional approach no longer meets the demand of the explosive growth of NM-based products. There is an emerging need to develop methods that can help design safe and effective NMs in an efficient manner. In this review article, we critically evaluate existing studies on in vivo pharmacokinetic properties, in vitro cellular uptake and release and kinetic modeling, and whole-body physiologically based pharmacokinetic (PBPK) modeling studies of different NMs. Methods on how to simulate in vitro cellular uptake and release kinetics and how to extrapolate cellular and tissue dosimetry of NMs from in vitro to in vivo via PBPK modeling are discussed. We also share our perspectives on the current challenges and future directions of in vivo pharmacokinetic studies, in vitro cellular uptake and kinetic modeling, and whole-body PBPK modeling studies for NMs. Finally, we propose a nanomaterial in vitro to in vivo extrapolation via physiologically based pharmacokinetic modeling (Nano−IVIVE−PBPK) framework for high-throughput screening of target cellular and tissue dosimetry as well as potential toxicity of different NMs in order to meet the demand of efficient evaluation of the safety, efficacy, and potential toxicity of a rapidly increasing number of NM-based products.

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“…They demonstrated that IBU@DhaTph-membrane dressing had excellent anti-infection and tissue remodeling activities by increasing local M2 macrophages and M2/M1 ratio, neovascularization and granulation tissue area, and collagen deposition. A study by Zhang et al [ 144 ] explored the anti-inflammatory and pro-healing effects of apoptotic-cell-inspired deformable phosphatidylserine-containing nanoliposomes on diabetic chronic wounds. The prepared system persistently bound to macrophage membranes and efficiently induced M2-like macrophage polarization, resulting in improved anti-inflammatory and pro-healing responses of macrophages, increased vascularization, and accelerated wound closure.…”

Section: Nanomedicines Targeting Macrophages For Wound Healingmentioning

confidence: 99%

Recent advances in nanomedicines for regulation of macrophages in wound healing

Joorabloo

Liu

2022

J Nanobiotechnol

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Macrophages are essential immune cells and play a major role in the immune response as pro-inflammatory or anti-inflammatory agents depending on their plasticity and functions. Infiltration and activation of macrophages are usually involved in wound healing. Herein, we first described macrophage polarization and their critical functions in wound healing process. It is addressed how macrophages collaborate with other immune cells in the wound microenvironment. Targeting macrophages by manipulating or re-educating macrophages in inflammation using nanomedicines is a novel and feasible strategy for wound management. We discussed the design and physicochemical properties of nanomaterials and their functions for macrophages activation and anti-inflammatory signaling during wound therapy. The mechanism of action of the strategies and appropriate examples are also summarized to highlight the pros and cons of those approaches. Finally, the potential of nanomedicines to modulate macrophage polarization for skin regeneration is discussed.

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Soft apoptotic-cell-inspired nanoparticles persistently bind to macrophage membranes and promote anti-inflammatory and pro-healing effects

Cited by 29 publications

References 45 publications

Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Integration of In Vitro and In Vivo Models to Predict Cellular and Tissue Dosimetry of Nanomaterials Using Physiologically Based Pharmacokinetic Modeling

Recent advances in nanomedicines for regulation of macrophages in wound healing

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