Soft-diet feeding decreases dopamine release and impairs aversion learning in Alzheimer model rats

Kushida, Sachio; Kimoto, Katsuhiko; Hori, Norio; Toyoda, Minoru; Karasawa, Nobuyuki; Yamamoto, Toshiharu; Kojo, Akiko; Onozuka, Minoru

doi:10.1016/j.neulet.2008.05.017

Cited by 51 publications

(39 citation statements)

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“…In animal and healthy human studies a causal association between mastication and cognition has been proposed. Research showed that reduced masticatory work by soft food (Kushida et al, 2008;Yamamoto and Hirayama, 2001) or cutting off the crown of molars (Onozuka et al, 1999;Watanabe et al, 2001) led to impairment of learning and memory in rodents. Interestingly, the impaired cognitive performance after cutting off molar crown can be partially rescued by reconstructing a prosthetic crown on the molar root (Watanabe et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Decision-making deficits associated with disrupted synchronization between basolateral amygdala and anterior cingulate cortex in rats after tooth loss

Cao

Wang

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Discussionmentioning

confidence: 99%

Decision-making deficits associated with disrupted synchronization between basolateral amygdala and anterior cingulate cortex in rats after tooth loss

Cao

Wang

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Chronic stress derived from reduced mastication has also been reported to enhance oxidative stress [26] and reduce the response of the dopamine (DA) neurons in the hippocampus, impairing the learning ability in the step-through passive avoidance test [27]. The DA projection from the midbrain dopamine cells of the ventral tegmental area (VTA) to the hippocampal neurons mainly regulates the late phase of LTP, which is essential for the settlement of long-term memory [28].…”

Section: Discussionmentioning

confidence: 99%

Loss of molars early in life develops behavioral lateralization and impairs hippocampus-dependent recognition memory

et al. 2014

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BackgroundUsing senescence-accelerated mouse prone 8 (SAMP8), we examined whether reduced mastication from a young age affects hippocampal-dependent cognitive function. We anesthetized male SAMP8 mice at 8 weeks of age and extracted all maxillary molar teeth of half the animals. The other animals were treated similarly, except that molar teeth were not extracted. At 12 and 24 weeks of age, their general behavior and their ability to recognize novel objects were tested using the open-field test (OFT) and the object-recognition test (ORT), respectively.ResultsThe body weight of molarless mice was reduced significantly compared to that of molar-intact mice after the extraction and did not recover to the weight of age-matched molar-intact mice throughout the experimental period. At 12 weeks of age, molarless mice showed significantly greater locomotor activity in the OFT than molar-intact mice. However, the ability of molarless mice to discriminate a novel object in the ORT was impaired compared to that of molar-intact mice. The ability of both molarless and molar-intact SAMP8 mice to recognize objects was impaired at 24 weeks of age. These results suggest that molarless SAMP8 mice develop a deficit of cognitive function earlier than molar-intact SAMP8 mice. Interestingly, both at 12 and 24 weeks of age, molarless mice showed a lateralized preference of object location in the encoding session of the ORT, in which two identical objects were presented. Their lateralized preference of object location was positively correlated with the rightward turning-direction preference, which reached statistical significance at 24 weeks of age.ConclusionsLoss of masticatory function in early life causes malnutrition and chronic stress and impairs the ability to recognize novel objects. Hyperactivation and lateralized rotational behavior are commonly observed with dysfunction of the dopaminergic system, therefore, reduced masticatory function may deplete the mesolimbic and mesocorticolimbic dopaminergic systems to impair the cognitive functions of selective attention and recognition memory in the prefrontal cortex and the hippocampus.

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“…The authors hypothesize that chewing resulting in cell proliferation is related to corticosterone levels [4]. Interestingly, independent studies have shown impairment in learning and memory abilities with similar soft diets [59,114]. If chewing plays a role in AHN, these data could be particularly relevant to the ageing population with cognitive decline where dental weakening might limit the chewing ability.…”

Section: Dietary Modulation Of Adult Hippocampal Neurogenesismentioning

confidence: 99%

Impact of diet on adult hippocampal neurogenesis

2009

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Research over the last 5 years has firmly established that learning and memory abilities, as well as mood, can be influenced by diet, although the mechanisms by which diet modulates mental health are not well understood. One of the brain structures associated with learning and memory, as well as mood, is the hippocampus. Interestingly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists. The level of neurogenesis in the adult hippocampus has been linked directly to cognition and mood. Therefore, modulation of adult hippocampal neurogenesis (AHN) by diet emerges as a possible mechanism by which nutrition impacts on mental health. In this study, we give an overview of the mechanisms and functional implications of AHN and summarize recent findings regarding the modulation of AHN by diet.

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Soft-diet feeding decreases dopamine release and impairs aversion learning in Alzheimer model rats

Cited by 51 publications

References 30 publications

Decision-making deficits associated with disrupted synchronization between basolateral amygdala and anterior cingulate cortex in rats after tooth loss

Decision-making deficits associated with disrupted synchronization between basolateral amygdala and anterior cingulate cortex in rats after tooth loss

Loss of molars early in life develops behavioral lateralization and impairs hippocampus-dependent recognition memory

Impact of diet on adult hippocampal neurogenesis

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