Abstract-Fresnel coefficients for three-layered uniaxially anisotropic media with arbitrarily oriented optic axes have been obtained using half-space reflection and transmission coefficients. The optic axes of the anisotropic media are assumed to be tilted at different angles ((ψ i , χ i ), i = 1, 2). This gives arbitrary orientation for anisotropic medium in the stratified configuration. The half space coefficients are derived at the boundary surfaces of two different media including isotropicanisotropic, anisotropic-anisotropic, anisotropic-isotropic interfaces with the application of boundary conditions. The interface between two media for the three-layered media leads to four different cases of wave propagation, which are analyzed in detail. The results are compared with the existing results in the limiting cases analytically. The results presented in this paper can be used to establish dyadic Green's functions, which can be used to calculate radiation and scattering from the stratified structure.