Soft Tissue Sarcoma Response to Two Cycles of Neoadjuvant Chemotherapy

Favinger, Jennifer L.; Hippe, Daniel S.; Davidson, Darin; Elojeimy, Saeed; Roth, Eira S.; Lindberg, Antoinette W.; Ha, Alice S.

doi:10.1016/j.acra.2017.10.013

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…The response evaluation by purely volumetric criteria, as measured by RECIST, is controversial in the sarcoma field. 16,[38][39][40][41] Hence, to account for these potential biases, we reported two different response evaluation methods. Third, surgery after palbociclib was limited to a subset of carefully selected patients.…”

Section: Discussionmentioning

confidence: 99%

“…Further, we noted a discrepancy between the prospective evaluation done by treating physicians at the time of treatment and our retrospective evaluation done according to RECIST, as expected. The response evaluation by purely volumetric criteria, as measured by RECIST, is controversial in the sarcoma field 16,38‐41 . Hence, to account for these potential biases, we reported two different response evaluation methods.…”

Section: Discussionmentioning

confidence: 99%

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Real‐world use of palbociclib monotherapy in retroperitoneal liposarcomas at a large volume sarcoma center

Nassif

Cope

Traweek

et al. 2022

Intl Journal of Cancer

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Palbociclib has been evaluated in early phase trials for well‐differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) patients, with reported median progression‐free survival (PFS) of 18 weeks. Here, we report on real‐world use and surgical outcomes associated with palbociclib treatment. We retrospectively reviewed 61 consecutive patients with retroperitoneal WDLPS (n = 14) or DDLPS (n = 47) treated with palbociclib monotherapy between 1 March 2016 and 28 February 2021 at The University of Texas MD Anderson Cancer Center. At palbociclib initiation, median age was 64 (interquartile range [IQR] 56‐72). In WDLPS and DDLPS cohorts, the median number of prior systemic treatments was 0 (IQR 0‐0) and 2 (IQR 0‐4), respectively. Median number of prior surgeries was 2 (WDLPS IQR 1‐2.75) and 2 (DDLPS IQR 1‐3). Median PFS was 9.2 (WDLPS IQR 3.9‐21.9) and 2.6 months (DDLPS IQR 2.0‐6.1), with median time on treatment of 7.4 months (WDLPS IQR 3.5‐14.2) and 2.7 months (DDLPS IQR 2.0‐5.7). Twelve patients ultimately underwent surgical resection. Resections were macroscopically complete (R0/R1) in half (n = 6/12), among whom only one patient experienced relapse after resection (median follow‐up 7.5 months). All patients who underwent macroscopically incomplete resections progressed after surgery with median time to progression of 3.3 months (IQR 2.3‐4.4). Surgery after palbociclib treatment was not associated with improved overall survival. Efficacy of palbociclib monotherapy for patients with advanced WDLPS and DDLPS is disappointing. While palbociclib may have been used to delay surgery, there was no clear benefit from treatment and few patients achieved prolonged tumor control.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Real‐world use of palbociclib monotherapy in retroperitoneal liposarcomas at a large volume sarcoma center

Nassif

Cope

Traweek

et al. 2022

Intl Journal of Cancer

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“…However, we have the opinion that the presence of perilesional oedema could be a useful tool for estimating OS in patients with MFS. Notably, perilesional oedema can increase, such as after neoadjuvant radiation therapy, making it difficult for the radiologist and the surgeon to evaluate the tumour volume as a part of preoperative planning (40).…”

Section: Figure 4 Kaplan-meier Curve Showing the Statistical Analysis...mentioning

confidence: 99%

Preoperative Evaluation of Myxofibrosarcoma: Prognostic Value and Reproducibility of Different Features on MRI

et al. 2020

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“…Magnetic Resonance Imaging (MRI) remains the imaging method of choice for the identification, characterization, local staging, and post-treatment follow-up of STS patients [ 17 ]. However, morphologic and size criteria based on conventional MRI sequences pre- and post-contrast enhancement cannot reliably assess histologic response [ 8 , 18 , 19 , 20 ]. Diffusion-Weighted Imaging (DWI) and Dynamic Contrast-Enhanced (DCE) imaging have also been used for neoadjuvant therapy response assessment in patients with STS [ 15 , 16 , 21 , 22 , 23 , 24 , 25 ] and an increase in Apparent Diffusion Coefficient (ADC) values following neoadjuvant therapy has been reported [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Prognostic Value of Pretherapeutic Magnetic Resonance Imaging in Predicting Soft Tissue Sarcoma Radiation Response: A Retrospective Study from a Large Institutional Sarcoma Imaging Database

Vogin,

Lepage,

Salleron

et al. 2024

Cancers

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Background: RT-induced hyalinization/fibrosis was recently evidenced as a significant independent predictor for complete response to neoadjuvant radiotherapy (RT) and survival in patients with soft tissue sarcoma (STS). Purpose: Non-invasive predictive markers of histologic response after neoadjuvant RT of STS are expected. Materials and Methods: From May 2010 to April 2017, patients with a diagnosis of STS who underwent neoadjuvant RT for limb STS were retrieved from a single center prospective clinical imaging database. Tumor Apparent Diffusion Coefficients (ADC) and areas under the time-intensity perfusion curve (AUC) were compared with the histologic necrosis ratio, fibrosis, and cellularity in post-surgical specimens. Results: We retrieved 29 patients. The median ADC value was 134.3 × 10−3 mm2/s. ADC values positively correlated with the post-treatment tumor necrosis ratio (p = 0.013). Median ADC values were lower in patients with less than 50% necrosis and higher in those with more than 50% (120.3 × 10−3 mm2/s and 202.0 × 10−3 mm2/s, respectively (p = 0.020). ADC values higher than 161 × 10−3 mm2/s presented a 95% sensitivity and a 55% specificity for the identification of tumors with more than 50% tumor necrosis ratio. Tumor-to-muscle AUC ratios were associated with histologic fibrosis (p = 0.036). Conclusions: ADC and perfusion AUC correlated, respectively, with radiation-induced tumor necrosis and fibrosis.

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Soft Tissue Sarcoma Response to Two Cycles of Neoadjuvant Chemotherapy

Cited by 7 publications

References 11 publications

Real‐world use of palbociclib monotherapy in retroperitoneal liposarcomas at a large volume sarcoma center

Real‐world use of palbociclib monotherapy in retroperitoneal liposarcomas at a large volume sarcoma center

Preoperative Evaluation of Myxofibrosarcoma: Prognostic Value and Reproducibility of Different Features on MRI

Evaluation of the Prognostic Value of Pretherapeutic Magnetic Resonance Imaging in Predicting Soft Tissue Sarcoma Radiation Response: A Retrospective Study from a Large Institutional Sarcoma Imaging Database

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