Soft Tissue Sarcoma—Review of Experience at a Tertiary Care Cancer Centre

Abstract

This study is a retrospective analysis of prospective data base of soft tissue sarcoma (STS) maintained in the department of Surgical Oncology, Bhim Rao Ambedkar Institute Rotary Cancer Hospital (BRA-IRCH), All India Institute of Medical Sciences, which is a tertiary care cancer centre. A total of 300 patients of STS were treated between 1995 and 2006. The mean age at presentation was 40.6 years and males were more affected then females. Extremity sarcomas were more common than non extremity sarcoma and lower limb dominated upper limb. The median size of tumor was 8 cm (range 1-40 cm). MRI scan was the preferred imaging modality and tissue diagnosis was obtained by core biopsy. Synovial Sarcoma and Malignant Fibrous Histiocytoma were the common histology. Majority (75%) tumors were of high grade. Patients were staged according to MSKCC staging system. Limb Salvage Surgery was offered to all patients where ever feasible. Wide excision with a gross three dimensional tumor free margin of 2 cm was performed. Adjuvant external beam radiotherapy was offered to all high grades, large and recurrent tumors along with perioperative brachytherapy implant for tumor bed. High grade tumors were also offered adjuvant Adriamycin based Chemotherapy. Limb salvage rate was 68% in extremity sarcoma. During follow up 114 (38%) patients had relapse of disease mainly systemic, lungs being the commonest site.

Efficacy and Safety of Endostar®Combined with Chemotherapy in Patients with Advanced Soft Tissue Sarcomas

“…To solve the problem that few options exist for the treatment of advanced sarcomas, researchers are doing intensive work in this field. Because of the hypersensitivity of STS, targeted therapies with better tolerance and less side effects are quite promising (Shukla et al, 2011;Purohit et al, 2011).…”

Prognostication of Soft Tissue Sarcomas

“…This was similar to the study conducted by Shukla et al in India which showed that the mean age of patients at presentation was 40.6 years. 7 STS were more common in the lower extremity ( Figure 10). Table 8 shows the common histologic types of soft tissue sarcomas compared to other studies.…”

Risk assessment of radio-chemotherapy in pediatric soft tissue sarcomas

“…Therefore, its management requires an experienced multidisciplinary team in an expert center (Faivre, & Le P echoux, 2013). They constitute about 1% of all solid tumors, (Shukla & Deo, 2011) and can occur in any part of the body (Umer, Umer, Qadir, Abbasi, and Masood, 2013). It present most commonly as an asymptomatic mass, and swelling was the presenting symptom in 96% patients (Shukla & Deo, 2011).…”

“…They constitute about 1% of all solid tumors, (Shukla & Deo, 2011) and can occur in any part of the body (Umer, Umer, Qadir, Abbasi, and Masood, 2013). It present most commonly as an asymptomatic mass, and swelling was the presenting symptom in 96% patients (Shukla & Deo, 2011). Their biological behavior is characterized by local aggressiveness and tendency to hematogenous spreading.…”

“…The goals of sarcoma management include both a cure and functional preservation of involved tissues and adjacent critical structures (Kandel et al, 2013). With the advances made in the fields of imaging, surgical, medical and radiation oncology along with better understanding of tumor pathology and biology more effective management protocols are currently available (Shukla & Deo, 2011). Treatment are often multimodal and complex, and patients can experience significant morbidity and mortality as a consequence of treatment or the disease (Kandel et al, 2013).…”