Soft-X-Ray Therapy in Bowen’s Disease and Erythroplasia of Queyrat

Abstract

The therapeutic results obtained with soft-X-ray irradiation on 77 lesions in 52 patients are reported. 35 males (67.3%) and 17 females (32.7%) were treated. Clinical and aistological features revealed Bowen’s disease in 73 cases (94.8%) and erythroplasia of Queyrat in 4 cases (5.2%). The primary healing was rated as 100% in all cases up to 6 months after a cumulative dosage of 3,200–5,000 R. 2 cases with a genital localization (2.6% of all sites and 11.1% of anogenital localizations) relapsed after 8 and 16 months, respectively. The follow-up period ranged from 1 to 11 years with a mean of 3 years. In order not to miss the late recurrences, the oncologic follow-up is taken care of by the Dermatology Department of the Zurich University Hospital during 10 years, or longer in some cases. Association with a malignant internal tumour (larynx, bronchi, anus) was found in 3 patients (5.8%).

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

“…95 Complete clearance of SCC in situ has also been reported following soft X-ray in 77 treated lesions, with healing in all cases and relapse in only two patients with genital disease over a mean 3-year follow-up period. 96 In a retrospective review of nine patients with digital SCC in situ, lesions were immersed in a water bath and treated with photon irradiation. The total median radiation dose delivered was 50 Gy (range 25-66 Gy) in 2Á5-Gy fractions (range 2-3 Gy).…”

Penile cancer

“…1,292 X-ray therapy should be reserved for those patients who refuse surgery and are therefore willing to accept a reduced cure rate. 8,293,294 More recently, imiquimod 5% cream 292,295-300 and photodynamic therapy with 20% d-aminolevulinic Multiple metastasis in a single organ M1d Metastasis in multiple organ sites J AM ACAD DERMATOL VOLUME 54,NUMBER 3 acid cream 301,302 have been used with encouraging results.…”

Bone Invasion by Squamous Cell Carcinoma In Situ (Bowen's Disease) of the Finger During Treatment With Imiquimod 5% Cream: Case Report

“…2 Although the best treatment option is surgical excision, many nonsurgical treatments, such as cryotherapy, 3 topical 5-fluororacil, 4 radiotherapy, 5 and laser therapy, 6 have been introduced for patients with poor medical conditions or for lesions with potentially poor wound healing capacity or poor cosmetic outcomes after surgery. However, no single treatment modality has been proven to be superior to any other.…”