The experiment on effect of different levels of organic and inorganic fertilizers on soil available nutrient status, nutrient uptake, yield, nutrient use efficiency and economics of summer groundnut (Arachis hypogaea L.) grown on Inceptisol was carried out at Agricultural Research Station, Kasbe Digraj, Dist: Sangli (MS) during summer 2019. The experimental soil was alkaline, calcareous, clay in texture, low in available nitrogen, medium in available phosphorus and very high in available potassium. The experiment was laid out in randomized block design with eight treatments and three replications. The treatment consist of T1-absolute control, T2-GRDF (25:50:00 N:P2O5:K2O kg ha -1 + 10 t FYM ha -1 ), T3-100% RDN through FYM, T4-100% RDN through press mud compost (PMC), T5-100% RDN through vermicompost, T6-50% RDN through FYM + 50% RDN through PMC, T7-50% RDN through FYM + 50% RDN through Vermicompost and, T8-33% RDN through FYM + 33% RDN through PMC + 33% RDN through vermicompost. Biofertilizers -Rhizobium, PSB-25 g kg -1 of seed were inoculated to all treatments except T1, which recommended dose of Pfertilizer (50 kg P2O5 ha -1 ) were applied to T3 to T8. The results revealed that the soil pH decreased and EC increased with the different levels of organic and inorganic fertilizers treatments over control. The organic carbon content (0.58%) and dehydrogenase enzyme activity(73.01 μg TPFg -1 soil 24 hr -1 ) in soil at harvest was higher in T2 as compare to rest of the treatments. The significantly the maximum total uptake of nitrogen (149.95 kg ha -1 ), phosphorus (28.27 kg ha -1 ) and potassium (79.45 kg ha -1 ) by groundnut was observed under T2 and it was at par with T5 (142.04 kg ha -1 ) for total uptake of nitrogen by groundnut. The Fe, Zn, Mn, and Cu content, uptake by kernel, haulm and total Fe, Zn, Mn, and Cu uptake by groundnut were statistically influenced by organic and inorganic fertilizers application. The treatment T2 was noticed significantly higher in dry pod yield (27.75 q ha -1 ) and dry haulm yield (49.86 q ha -1 ). The T2 was at par with T5 (26.94 q ha -1 ) regarding dry pod yield of groundnut. Apparent recovery of nitrogen (190.44%) and agronomic efficiency (15.64 kg ha -1 ) of nitrogen were noticed higher in 100% RDN through vermicompost as compare to remaining treatments. The highest B:C ratio was obtained in application of 100% RDN through vermicompost. It is concluded from the study that under biofertilizer seed treatment, the application of GRDF (25:50:00 N:P2O5:K2O kg ha -1 + 10 t FYM ha -1 ) or application of 100% recommended dose of nitrogen through vermicompost alongwith 50 kg P2O5 ha -1 to groundnut recorded higher soil available nutrients, nutrient uptake, yield, nutrient use efficiency and net monetary returns from groundnut.