Soil-Transmitted Helminth Infections Are Associated With an Increase in Human Papillomavirus Prevalence and a T-Helper Type 2 Cytokine Signature in Cervical Fluids

Gravitt, Patti E.; Marks, Morgan A.; Kosek, Margaret; Huang, Christine; Cabrera, Lilia; Olórtegui, Maribel Paredes; Medrano, Alberto Mejia; Trigoso, Dixner Rengifo; Qureshi, Sarah; Bardales, Gustavo Sarria; Manrique-Hinojosa, Javier; Cardenas, Albert Z.; Larraondo, M Alvarez; Cok, Jaime; Qeadan, Fares; Siracusa, Mark C.; Gilman, Robert H.

doi:10.1093/infdis/jiv498

Cited by 24 publications

(36 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, as a result of their social habits, Hadza and Matses are more exposed to enteric viruses, which can end up in the environment through the discharge of waste material from infected people (Rzezutka and Cook, ). Finally, in a recent interesting study, soil‐transmitted helminth infections were found to be associated with the increase in human papillomavirus prevalence in people living in the Peruvian Amazon (Gravitt et al ., ), the same region of Matses. Thus, it is tempting to speculate that the higher contribution of Betapapillomavirus to the gut virome of this traditional population could be partially attributable to living in helminth‐endemic areas.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Rampelli

Turroni

Schnorr

et al. 2017

Environmental Microbiology

View full text Add to dashboard Cite

It is a matter of fact that the human gut microbiome also includes a non-bacterial fraction represented by eukaryotic cells and viruses. To further explore the gut microbiome variation in human populations, here we characterized the human DNA viral community from publicly available gut metagenome data sets from human populations with different geographical origin and lifestyle. In particular, such data sets encompass microbiome information from two western urban societies (USA and Italy), as well as two traditional hunter-gatherer communities (the Hadza from Tanzania and Matses from Peru) and one pre-agricultural tribe (Tunapuco from Peru). Our results allowed for the first taxonomic reconstruction of the complex viral metacommunities within the human gut. The core virome structure included herpesviruses, papillomaviruses, polyomaviruses, adenoviruses and anelloviruses. Using Random Forests and a co-occurrence analysis approach, we identified the viruses that distinguished populations according to their geographical origin and/or lifestyle. This paves the way for new research aimed at investigating the biological role of the gut virome in human physiology, and the importance of our viral counterpart in the microbiome-host co-evolutionary process.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Rampelli

Turroni

Schnorr

et al. 2017

Environmental Microbiology

View full text Add to dashboard Cite

show abstract

“…A P value of < 0.01, after Sidak's correction for multiple comparisons, was considered statistically significant. 18,[22][23][24] Bartlett's test was applied to assess the equality of variance-covariance matrices. To gain a bigger picture of the results, canonical correlation was used to calculate the multivariate association between the two sets of variables.…”

Section: Discussionmentioning

confidence: 99%

“…Spearman's rank correlation was estimated to identify patterns of coexpression. A P value of < 0.01, after Sidak's correction for multiple comparisons, was considered statistically significant . Bartlett's test was applied to assess the equality of variance–covariance matrices.…”

Section: Methodsmentioning

confidence: 99%

“…A study population was sampled from a larger study of women designed to assess differences in cervical human papillomavirus prevalence in Peruvian populations, Iquitos and Lima, with and without endemic soil-transmitted helminthic infections, respectively. 18 Women were eligible if they were between 25 and 45 years of age and had an intact uterus. The study was approved by the Johns Hopkins University and AB-PRIMSA (Asociaci on Ben efica-PRISMA) institutional review boards/ ethics committee.…”

Section: Study Populationmentioning

confidence: 99%

See 1 more Smart Citation

Oral sampling methods are associated with differences in immune marker concentrations

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Indeed, several human studies suggest that helminth co-infections worsen the outcome of a virus infection [10]. For instance, individuals infected with soil-transmitted helminths, filarial nematodes or water-borne schistosomes, were more susceptible to infection by the human immunodeficiency virus (HIV) [11, 12], hepatitis C virus [13] and human papillomavirus [14] and/or suffered from increased pathology [13, 15]. Drug-induced deworming decreased HIV loads [11, 16–18] in some studies, while anthelminthic treatments had no beneficial effect on HIV infection in other studies [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads

et al. 2016

View full text Add to dashboard Cite

Worldwide more than 2 billion people are infected with helminths, predominantly in developing countries. Co-infections with viruses such as human immunodeficiency virus (HIV) are common due to the geographical overlap of these pathogens. Helminth and viral infections induce antagonistic cytokine responses in their hosts. Helminths shift the immune system to a type 2-dominated immune response, while viral infections skew the cytokine response towards a type 1 immune response. Moreover, chronic helminth infections are often associated with a generalized suppression of the immune system leading to prolonged parasite survival, and also to a reduced defence against unrelated pathogens. To test whether helminths affect the outcome of a viral infection we set up a filarial/retrovirus co-infection model in C57BL/6 mice. Although Friend virus (FV) infection altered the L. sigmodontis-specific immunoglobulin response towards a type I associated IgG2 isotype in co-infected mice, control of L. sigmodontis infection was not affected by a FV-superinfection. However, reciprocal control of FV infection was clearly impaired by concurrent L. sigmodontis infection. Spleen weight as an indicator of pathology and viral loads in spleen, lymph nodes (LN) and bone marrow (BM) were increased in L. sigmodontis/FV-co-infected mice compared to only FV-infected mice. Numbers of FV-specific CD8+ T cells as well as cytokine production by CD4+ and CD8+ cells were alike in co-infected and FV-infected mice. Increased viral loads in co-infected mice were associated with reduced titres of neutralising FV-specific IgG2b and IgG2c antibodies. In summary our findings suggest that helminth infection interfered with the control of retroviral infection by dampening the virus-specific neutralising antibody response.

show abstract

Soil-Transmitted Helminth Infections Are Associated With an Increase in Human Papillomavirus Prevalence and a T-Helper Type 2 Cytokine Signature in Cervical Fluids

Abstract: A proportion of the increased HPV prevalence at older ages observed in Latin America may be due to a population-level difference in the efficiency of immunological control of HPV across the lifespan due to endemic STH infection.

Cited by 24 publications

References 35 publications

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Oral sampling methods are associated with differences in immune marker concentrations

Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads

Contact Info

Product

Resources

About