Sol–Gel Processed Oxide Controlled Release Materials

Qu, Haibo; Bhattacharyya, Sanjib; Ducheyne, Paul

doi:10.1016/b978-0-08-055294-1.00138-0

Cited by 7 publications

(7 citation statements)

References 140 publications

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“…Xerogels are supposed to lose their structure due to evaporation at room temperature. On the contrary, cryogel cross‐section images are more significant, since freeze drying from the hydrated form is supposed to maintain the bulk network, as reported in the literature [60] …”

Section: Resultsmentioning

confidence: 89%

Waste Cleaning Waste: Combining Alginate with Biowaste‐Derived Substances in Hydrogels and Films for Water Cleanup

Tummino

Nisticò

Riedo

et al. 2020

Chemistry A European J

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Biowaste‐derived substances isolated from green compost (BBS‐GC) are environmentally friendly reactants similar to humic substances, which contain multiple functionalities, that are suitable for adsorbing different kinds of pollutants in wastewater. Herein, sodium alginate (derived from brown algae) cross‐linked with both Ca2+ ions and BBS‐GC in the form of hydrogels and dried films are proposed as green, easy‐to‐form, and handleable materials for tertiary water treatments. The results show that both hydrogels and films are mechanically stable and can effectively remove differently charged dyes through an adsorption mechanism that can be described by the Freundlich model. BBS‐GC‐containing gels always performed better than samples prepared without BBS‐GC, revealing that such unconventional materials can integrate waste valorization and water decontamination, potentially providing social and environmental benefits.

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Section: Resultsmentioning

confidence: 89%

Waste Cleaning Waste: Combining Alginate with Biowaste‐Derived Substances in Hydrogels and Films for Water Cleanup

Tummino

Nisticò

Riedo

et al. 2020

Chemistry A European J

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“…1 For that purpose, several drug-delivery systems (DDS) have been formulated and/or are being investigated for drug administration (e.g., intravenous, oral, nasal). 2 , 3 Among them, metal–organic frameworks (MOFs) have recently emerged as original promising DDS. 4 − 7 MOFs are crystalline solids based on metal ions subunits coordinated to organic polydentate ligands, leading to the formation of highly porous structures.…”

Section: Introductionmentioning

confidence: 99%

“…Once administered, therapeutic drugs should be in a concentration at which full efficacy is achieved with no associated side effects . For that purpose, several drug-delivery systems (DDS) have been formulated and/or are being investigated for drug administration (e.g., intravenous, oral, nasal). , Among them, metal–organic frameworks (MOFs) have recently emerged as original promising DDS. − MOFs are crystalline solids based on metal ions subunits coordinated to organic polydentate ligands, leading to the formation of highly porous structures . Their structural/chemical diversity and exceptional porosity (Brunauer–Emmett–Teller (BET) surface ( S BET ) up to 7000 m 2 ·g –1 ) together with their amphiphilic internal microenvironment are thus well adapted to the adsorption of a large variety of guest molecules, including the therapeutic ones (e.g., drugs, cosmetics, biological gases, enzymes). ,, …”

Section: Introductionmentioning

confidence: 99%

Toward Understanding Drug Incorporation and Delivery from Biocompatible Metal–Organic Frameworks in View of Cutaneous Administration

et al. 2018

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Although metal–organic frameworks (MOFs) have widely demonstrated their convenient performances as drug-delivery systems, there is still work to do to fully understand the drug incorporation/delivery processes from these materials. In this work, a combined experimental and computational investigation of the main structural and physicochemical parameters driving drug adsorption/desorption kinetics was carried out. Two model drugs (aspirin and ibuprofen) and three water-stable, biocompatible MOFs (MIL-100(Fe), UiO-66(Zr), and MIL-127(Fe)) have been selected to obtain a variety of drug–matrix couples with different structural and physicochemical characteristics. This study evidenced that the drug-loading and drug-delivery processes are mainly governed by structural parameters (accessibility of the framework and drug volume) as well as the MOF/drug hydrophobic/hydrophilic balance. As a result, the delivery of the drug under simulated cutaneous conditions (aqueous media at 37 °C) demonstrated that these systems fulfill the requirements to be used as topical drug-delivery systems, such as released payload between 1 and 7 days. These results highlight the importance of the rational selection of MOFs, evidencing the effect of geometrical and chemical parameters of both the MOF and the drug on the drug adsorption and release.

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“…However, TEOS and water are immiscible, and thus ethanol, which acts as a homogenizing agent, was used to facilitate the hydrolysis process [ 16 ]. The presence of ethanol results in miscibility of alkoxide and water, which form a homogeneous solution [ 17 , 18 ]. HCl was added to the solution to shorten the hydrolysis time and hasten the gelation of the sol, since Si(OR) 4 reacts slowly in water and alcohol.…”

Section: Resultsmentioning

confidence: 99%

“…Under acidic conditions, the condensation reaction, which involves protonated silanol species, makes the silicon more electrophilic and thus more prone to nucleophilic attack. Hence, this condition induces the condensation reaction that occurs between neutral species and protonated silanol situated at the end groups of chains, resulting in the creation of siloxane networks [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of New Sol–Gel Hybrid Inulin–TEOS Adsorbent

Yusop

Ismail

2021

Polymers

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A new biopolymer–silica hybrid material consisting of inulin and tetraethoxysilane (TEOS) for use as an adsorbent was successfully synthesized via the sol–gel method in acidic conditions. The hydrolysis and condensation processes were attained in water/ethanol solution. Three molar ratios of inulin:TEOS (1:1, 1:2, and 2:1) were prepared and dried at various temperatures (50, 60, and 70 °C). The optimized molar ratio of 2:1 with a drying temperature of 70 °C was found to obtain the best morphology and characteristics for absorbent properties. Fourier transform infrared spectroscopy (FTIR) analysis showed a strong interaction between inulin and TEOS, which was also observed using energy dispersive X-ray spectroscopy (EDX). Field emission scanning electron microscopy (FESEM) images revealed the presence of nanoparticles on the rough surface of the hybrid sol–gel. X-ray diffractometer (XRD) analysis showed the amorphous state of the silica network where the inulin existed as an anhydrous crystalline phase. Brunauer–Emmet–Teller (BET) analysis confirmed that the composite was mesoporous, with 17.69 m2/g surface area and 34.06 Å pore size. According to thermogravimetric analysis (TGA) results, the hybrid inulin-TEOS adsorbent was thermally stable under a temperature of 200 °C.

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Sol–Gel Processed Oxide Controlled Release Materials

Cited by 7 publications

References 140 publications

Waste Cleaning Waste: Combining Alginate with Biowaste‐Derived Substances in Hydrogels and Films for Water Cleanup

Waste Cleaning Waste: Combining Alginate with Biowaste‐Derived Substances in Hydrogels and Films for Water Cleanup

Toward Understanding Drug Incorporation and Delivery from Biocompatible Metal–Organic Frameworks in View of Cutaneous Administration

Preparation and Characterization of New Sol–Gel Hybrid Inulin–TEOS Adsorbent

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