Solar keratoses: Analysis in a dermatological practice in Australia

Rosén, Robert; Studniberg, Howard M.

doi:10.1046/j.1440-0960.2002.00634.x

Cited by 8 publications

(9 citation statements)

References 19 publications

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“…Lesions were usually distributed on the face in Chinese patients but rarely on the trunk or extremities. The incidence on the extremities and trunk was lower than found in Caucasians [16,17,18]. This might be due to cultural differences (e.g.…”

Section: Discussionmentioning

confidence: 70%

Clinical and Pathological Study of 328 Cases of Actinic Keratosis in Eastern Chinese Patients

Han

Chen²,

Dou³

et al. 2013

Dermatology

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Background: Actinic keratosis (AK) is prevalent and has been widely studied in fair-skinned populations. However, this is not the case in eastern countries. AK in Asians has not been so thoroughly investigated. Objectives: To analyse the clinical and pathological features of a relatively large number of cases of AK diagnosed in older Chinese patients. Methods: Case histories of 328 patients with pathologically diagnosed AK were analysed retrospectively. Their demographic, clinical, pathological and treatment data were collected for analysis of associated factors. Results: Lesions were usually distributed on the face, especially the cheeks and temples. The most frequent pathological type was hypertrophic. Only 34% of the cases had been diagnosed correctly as AK before biopsy; many were mistaken for seborrhoeic keratosis. Conclusions: Most patients were elderly females and there was a higher incidence of lesions on the face, and a lower incidence on the extremities and trunk; this finding contrasts with previous investigations in fair-skinned people.

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Section: Discussionmentioning

confidence: 70%

Clinical and Pathological Study of 328 Cases of Actinic Keratosis in Eastern Chinese Patients

Han

Chen²,

Dou³

et al. 2013

Dermatology

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“…Die Prävalenz aktinischer Keratosen wurde in einer amerikanischen Studie mit 11% der über 20-Jährigen und 25% der über 30-Jährigen beziffert [9].Memon et alberichten von einer Prävalenz von 15% bei der über 40-jährigen britischen Bevölkerung [22]. Bei einer Prävalenz der nördlichen Hemisphäre von approximativ 15% der über 40-Jährigen sind alleine in Deutschland bis zu 10 Mio.Menschen von AK betroffen.In Australien liegt die Prävalenz aktinischer Keratosen sogar bei 45% der über 40-Jährigen, wobei im Patientendurchschnitt 8 Keratosen beobachtet werden können [26].…”

Section: Epidemiologieunclassified

“…20% der AK werden Spontanremissionen beobachtet [21]. Durch Analyse benachbarter AK und metastasierender spinozellulärer Karzinome konnte jedoch gezeigt werden, dass ein signifikanter Anteil der AK in ein invasives spinozelluläres Karzinom übergeht.Das Risiko des Übergangs in ein invasives spinozelluläres Karzinom wird unterschiedlich beurteilt, bis zu 16% aller AK können innerhalb von 10 Jahren in ein invasives SCC übergehen [7,13,21,26]. Aufgrund der korrespondierenden Ätiologie findet sich in der dermalen Umgebung von aktinischen Keratosen fast immer eine aktinische Elastose.Ein chronisch-entzünd-liches Infiltrat wird ebenfalls oft beobachtet.Auf zytologischer Ebene sind aktinische Keratosen -oder treffender initiale spinozelluläre Karzinome -von SCC nicht zu unterscheiden.…”

Section: Klinikunclassified

“…In einer amerikanischen Studie konnte in 97% von 459 untersuchten SCC eine Assoziation mit unmittelbar benachbart liegenden AK dargestellt werden [14]. Dinehart et al beschrieben AK in der Nachbarschaft von 44% aller untersuchten metastasierten SCC [5].Insgesamt ist eine steigende Inzidenz von AK und SCC zu verzeichnen, wobei das theoretisches Risiko der Ausbildung eines invasiven SCC aus AK innerhalb von 10 Jahren zwischen 0,025% und 16% liegt [7,13,21,26].…”

Section: Diskussionunclassified

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Die aktinische Keratose

2003

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Actinic keratoses are defined as proliferation of cytologically atypical keratinocytes in the zone of epidermal-dermal junction in photodamaged skin. In the northern hemisphere the prevalence of actinic keratoses ranges depending on different epidemiological studies from 11% to 25% for people aged 40 or older. The main cause of actinic keratoses is exposure to UVB radiation in sunlight UVB radiation induces mutations in the telomerase gene and in the tumor suppressor gene P53, which can also be detected in invasive squamous cell carcinoma. The only histological parameter to distinguish between actinic keratoses and SCC is the level of invasiveness. The risk for actinic keratoses to develop into SCC is about 16% over lo years. For this reason and because of the high prevalence of actinic keratoses, it has been suggested to replace the term,, actinic keratosis K with intraepidermal squamous cell carcinoma' to better characterize the lesion. In the following review recent aspects of pathogenesis and therapy of actinic keratoses are discussed.

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“…Solar (actinic) keratoses (SK) are precursors to squamous cell carcinoma (SCC) 1,2 . SK are also markers of risk for invasive disease developing on regions of the skin with the highest exposure to ultraviolet light 3 . In this study, we prospectively determined the risk of skin cancer developing in patients with biopsy‐proven SK.…”

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confidence: 99%