An experiment to determine the performance of a thermoelectric powered by solar panel for a large cooler box was carried out. The size of the cooler box tested was 1000 mm x 500 mm x 400 mm and inside the cooler box, a plastic bottle containing 19 liters of water was placed. The thermoelectric hot side was cooled using a mini channel flowed with water. Meanwhile, the cold side of the thermoelectric was connected to the inner heat sink to absorb heat inside the cooler box. The thermoelectric was powered from a battery charged by solar panels directly. There were 2 solar panels, each of which had a power of 100 WP. The cooler box was tested for 6 days in June 2019. The results showed that the lowest temperature on the thermoelectric cold side was around 16.21°C, while the lowest temperature inside the cooler box was 24.25°C. The experimental COPs obtained were ranging from 0.01 to 0.76. Moreover, in general, solar panels were potential as power sources for thermoelectric cooling systems.