Solar UVR and Variations in Systemic Immune and Inflammation Markers

Abstract

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Skin Barrier– and Immune Response–Related Biomarkers of Solar UVR Exposure Comparing Indoor and Outdoor Workers

“…CCL4, also known as MIP-1β, is a cytokine involved in attraction of leukocytes toward inflamed skin sites. Interestingly, Mai et al (2021) reported an inversed association between blood CCL4 levels and solar UVR exposure in a population-based study.…”

The Immune Response of Cutaneous Basosquamous- and Squamous-Cell Carcinoma Associated with Sun Exposure

“…Martincorena et al utilized genomic sequencing to show that prolonged sun exposure leads to mutations in keratinocytes long before the appearance of precancerous lesions and squamous skin carcinomas [24]. Thus, at the epithelial level, DNA changes and prolonged exposure to the sun are associated with the development and progression of certain cancers [25,26].…”