Solid Cell Nests in Hashimoto’s Thyroiditis Sharing Features with Papillary Thyroid Microcarcinoma

Asioli, Sofia; Erickson, Lori A.; Lloyd, Ricardo V.

doi:10.1007/s12022-009-9095-x

Cited by 48 publications

(29 citation statements)

References 30 publications

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“…SCNs may represent a pool of stem cells in the adult thyroid gland (Reis-Filho et al 2003, Preto et al 2004, Asioli et al 2009, Rios Moreno et al 2011. In fact, in mixed follicles, the continuity between main cells and follicular cells was considered to indicate that the latter are produced through a maturation process of the main cells of SCNs (Cameselle-Teijeiro et al 2005).…”

Section: Thyroid Stem Cells and Cscs Identificationmentioning

confidence: 99%

Cancer stem-like cells and thyroid cancer

Guo¹,

Hardin²,

Lloyd³

2014

Endocrine Related Cancer

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Thyroid cancer is one of the most rapidly increasing malignancies. The reasons for this increase is not completely known, but increases in the diagnosis of papillary thyroid microcarcinomas and follicular variant of papillary thyroid carcinomas along with the enhanced detection of well-differentiated thyroid carcinomas are probably all contributing factors. Although most cases of well-differentiated thyroid carcinomas are associated with an excellent prognosis, a small percentage of patients with well-differentiated thyroid carcinomas as well as most patients with poorly differentiated and anaplastic thyroid carcinomas have recurrent and/or metastatic disease that is often fatal. The cancer stem-like cell (CSC) model suggests that a small number of cells within a cancer, known as CSCs, are responsible for resistance to chemotherapy and radiation therapy, as well as for recurrent and metastatic disease. This review discusses current studies about thyroid CSCs, the processes of epithelial-to-mesenchymal transition (EMT), and mesenchymal-to-epithelial transition that provide plasticity to CSC growth, in addition to the role of microRNAs in CSC development and regulation. Understanding the biology of CSCs, EMT and the metastatic cascade should lead to the design of more rational targeted therapies for highly aggressive and fatal thyroid cancers.

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Section: Thyroid Stem Cells and Cscs Identificationmentioning

confidence: 99%

Cancer stem-like cells and thyroid cancer

Guo¹,

Hardin²,

Lloyd³

2014

Endocrine Related Cancer

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“…25 Currently another hypothesis considered for pathogenesis of papillary cancer in Hashimoto's thyroiditis is solid cell nest (SCN), which measure 0.1 mm or less in diameter and consist of polygonal to ovoid cells with elongated nuclei, finely granular chromatin, and may show nuclear grooves. 26 SCN may be misinterpreted as papillary thyroid microcarcinoma, squamous metaplasia of follicular thyroid cells, primary or metastatic squamous cell carcinoma, thyroglossal cyst, C-cell hyperplasia, and medullary microcarcinoma. The distinction between these lesions and SCN can sometimes be made based on the hematoxylin and eosin (H and E) appearance, but often needs immunohistochemistry for confirmation.…”

Section: Discussionmentioning

confidence: 99%

Hashimoto’s thyroiditis-a tertiary level hospital based study

Manikantan

Chisthi

2017

Int J Res Med Sci

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Background: Hashimoto's disease is a chronic, autoimmune form of thyroiditis and is one of the most common causes for hypothyroidism. Many studies have found an association between Hashimoto's thyroiditis and various other thyroid pathologies, including cancers. The objectives of the study were to look for any association between Hashimoto's thyroiditis and other forms of thyroid diseases and to analyse the pattern of patients treated with Hashimoto's thyroiditis. Methods: This was a retrospective study conducted at a tertiary care centre from December 2008 to January 2014. Patients with Hashimoto's thyroiditis confirmed by histology were selected as the cases. Their clinical and biochemical data and post-operative histopathological reports were collected and analysed. Results: 300 patients who underwent thyroidectomy were found to have a diagnosis of Hashimoto's thyroiditis. 97.33% of the patients were females. Maximum patients belonged to the 31-40 age group. Of the 300 patients, 61.67% had other associated pathologies. The maximum association was with colloid goiters, followed by adenomas and malignancies. Among the malignancies, 80.65% were papillary cancers while the rest were follicular cancers. There were no cases of other malignancies associated with Hashimoto's thyroiditis. Conclusions: Hashimoto's thyroiditis is fairly common in the studied population, mostly among females. It is associated with other thyroid pathologies including differentiated cancers. Lymphoma is not found to be associated with Hashimoto's disease in our population. Hashimoto's thyroiditis thus forms a major share of goiters leading to thyroidectomy in Indian population. However, the decision to operate should be primarily governed by the associated cytology.

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“…Solid cell nests may be mistaken for papillary thyroid carcinomas (PTCs) and for squamous metaplasia. They stain for low molecular weight keratin and polyclonal carcinoembryonic antigen, and may show variable staining for calcitonin [ 15 ] Fig. 1.9 Solid cell nests.…”

Section: Fig 16mentioning

confidence: 99%