Solid drug particles encapsulated bead-on-string nanofibers: the control of bead number and its corresponding release profile

Electrospun nanofibres in drug delivery: advances in controlled release strategies

“…Tingxiao Li et al (2019) explored and validated the potential of beads on string nanofibres made up of PLGA, as an excipient for micro-level solid drug particles of tetracycline hydrochloride (antibiotic drug). 62 As per the study, the bead number and bead diameter were crucial factors in drug release. The bead number defines the encapsulation capability or drug loading capability, whereas the bead diameter or size majorly contributes in determining the drug-release kinetics.…”

“…The bead number defines the encapsulation capability or drug loading capability, whereas the bead diameter or size majorly contributes in determining the drug-release kinetics. 62 Bigger sized beads were found to lower the initial burst release, whereas, an increased number of beads increased the total drug release. Thus, a uniform-sized bead distribution is desired to estimate the drug-release mechanism.…”

“…The most engaging feature of beads on string nanofibres is the formation of 3D nanofibres with macro-pores, which paves a way for regenerative medicine. 62 Tingxiao Li et al (2020) successfully encapsulated bovine serum albumin with growth factors in the core side into beaded nanofibres of polylactic acid- co-ε -caprolactone (shell side). The as-prepared scaffold showed good attachment and the spread of human mesenchymal stem cells onto the surface of the core and shell nanofibres with the sustained release of growth factors.…”

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

“…Besides, in terms of size, micro-range beads are more suitable than nanofibers to serve as reservoirs for bioactive agents or drugs. 100 Nowadays, more electrospun bead-on-string nanofibers are explored as promising carriers of solid drug particles 101 (Figure 4 (c)). Researchers controlled bead number by tailoring electrospinning parameters like voltage, flow rate and distance so as to determine the encapsulation capability.…”

Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs

“…In recent years, with the increasing advantages of micro-nano structures, some researchers have noticed unique features of beads-on-a-string and discovered that drug release could be adjusted by controlling the size of particles [ 58 , 59 ]. According to the research findings, beads-on-a-string can be prepared by uniaxial and coaxial electrospinning [ 60 , 61 , 62 , 63 , 64 , 65 , 66 ], and particle diameter can be adjusted through changing polymer solution concentration and drug-loaded [ 59 ].…”