Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin permeation and retention of hydrophilic drugs l-ascorbic acid

Moringia oleifera Lam. seeds isothiocyanate against skin photoaging by regulating p38MAPK-dependent autophagy signalling pathway

“…Vc has multiple functions in the skin, such as collagen synthesis, decolorization and antioxidant activity. Studies have found that the combination of collagen peptide and Vc can promote the proliferation of HaCaT cells induced by ultraviolet radiation [20] . Gavage administration of Vc and collagen peptide can also increase the content of type I collagen and the expression of antioxidant enzymes, inhibit the expression of metalloproteinases, and regulate the Nrf2/ARE and TGF-β/Smad pathways, thereby improving the ultraviolet-induced mouse skin photoaging model [19] .…”