2014
DOI: 10.2174/156720181106141202122335
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Solid Lipid Nanoparticles: Promising Therapeutic Nanocarriers for Drug Delivery

Abstract: Development of colloidal delivery systems has opened new avenues/frontiers for improving drug delivery. Solid lipid nanoparticles have come up as the latest development in the arena of lipid based colloidal delivery systems after nanoemulsion and liposomes ever since their introduction in the early 1990s. In this review, the authors have made efforts to bring forth the essential and practically relevant aspects of SLNs. This review gives an overview of the preparation methods of solid lipid nanoparticles while… Show more

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Cited by 54 publications
(29 citation statements)
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“…They are prepared mainly with phospholipids and solid lipids, which are generally considered safe, biocompatible, and biodegradable (Thukral et al, 2014;Misra et al, 2016). They can be a good alternative to polymeric systems due to their unique structure and properties, such as lower toxicity, the ability to protect active pharmaceutical ingredient from chemical degradation, and prolonged drug release.…”
Section: Introductionmentioning
confidence: 99%
“…They are prepared mainly with phospholipids and solid lipids, which are generally considered safe, biocompatible, and biodegradable (Thukral et al, 2014;Misra et al, 2016). They can be a good alternative to polymeric systems due to their unique structure and properties, such as lower toxicity, the ability to protect active pharmaceutical ingredient from chemical degradation, and prolonged drug release.…”
Section: Introductionmentioning
confidence: 99%
“…25 SLNs combine the advantages of the traditional systems and avoid some of their major disadvantages, including controllable drug release, enhanced bioavailability of poorly water-soluble drugs, and alleviated drug efflux to overcome multidrug resistance. 26,27 NLCs, a new generation of SLNs, consist of a solid lipid matrix with a certain amount of liquid lipid.…”
Section: Introductionmentioning
confidence: 99%
“…20 SLNs are made from solid lipids with a mean diameter of 50 to 1,000 nm, which exhibit biocompatibility, physical stability, controlled release properties, and ease of manufacture. 21 SLN systems represent a promising platform both for conjugating PEG, thus achieving long circulation in vivo, and for incorporation of active targeting ligand.…”
Section: Introductionmentioning
confidence: 99%