Solid-lipid nanoparticles (SLN)s containing Zataria multiflora essential oil with no-cytotoxicity and potent repellent activity against Anopheles stephensi

Kelidari, Hamid Reza; Moemenbellah‐Fard, Mohammad Djaefar; Morteza‐Semnani, Katayoun; Amoozegar, Fatemeh; Shahriari-Namadi, Marziae; Saeedi, Majid; Osanloo, Mahmoud

doi:10.1007/s12639-020-01281-x

Cited by 40 publications

(12 citation statements)

References 27 publications

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“…Furthermore, some reports on using other nanoformulations as mosquito repellents have been published, e.g., solid-lipid nanoparticles containing Zataria multiflora (1%) with CPT 95 min against An. stephensi [ 30 ]. In another work, chitosan nanoparticles containing the C. zeylanicum EO (0.5%) were applied against An.…”

Section: Discussionmentioning

confidence: 99%

A Nanoliposomal Gel Containing Cinnamomum zeylanicum Essential Oil with Effective Repellent against the Main Malaria Vector Anopheles stephensi

Osanloo

Firoozian

Zarenezhad

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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Malaria is the most important vector-borne disease; however, mosquito repellents are still a practical approach for controlling malaria, especially in endemic regions. Due to the side effects of synthetic repellents such as N, N-diethyl-meta-toluamide (DEET), the development of natural repellents has received much attention. In this study, nanoliposomes containing 0.5 and 2.5% w/v Cinnamomum zeylanicum essential oil were firstly prepared with particle sizes of 119 ± 6 and 195 ± 9 nm. Their morphologies and loading of the essential oil in the particles were then investigated using transmission electron microscopy (TEM) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) analyses. The nanoliposomes were finally jellified to increase their viscosity and facilitate topical usage. The complete protection time of the nanoliposomal gel containing 2.5% C. zeylanicum essential oil was significantly longer than that of 2.5% DEET against Anopheles stephensi: 303 ± 10 > 242 ± 12 min, p < 0.001 . Moreover, the prepared nanoformulation was stable for at least six months at 4 and 26°C. Therefore, the prepared prototype could be considered a natural repellent against the main malaria mosquito vector in field conditions. In addition, it is suggested to be investigated against other important factors mosquitoes.

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Section: Discussionmentioning

confidence: 99%

A Nanoliposomal Gel Containing Cinnamomum zeylanicum Essential Oil with Effective Repellent against the Main Malaria Vector Anopheles stephensi

Osanloo

Firoozian

Zarenezhad

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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“…For instance, a solid lipid nanoparticle containing 1% Zataria multiflora EO was introduced with a 90 min protection time against An. stephensi [ 45 ]. Besides, the literature reported nanoemulsions containing 15% Eucalyptus globulus EO with 170 min protection time against a mixture of mosquitoes [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Nanogels Containing Foeniculum vulgare Mill. and Mentha piperita L. Essential Oils: Mosquitoes’ Repellent Activity and Antibacterial Effect

Sanei-Dehkordi

Abdollahi

Safari

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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Foeniculum vulgare Mill. and Mentha piperita L. are two common medicinally important plants with a wide range of biological activities such as insecticide and antibacterial effects. In this study, the chemical composition of their essential oils was investigated using GC-MS analysis. After that, their nanoemulsions were prepared; optimum samples with droplet sizes of 74 ± 7 and 136 ± 5 nm were gelified. The viscosity of the prepared nanogels and the successful loading of the essential oil in them were investigated. The efficacy of the nanogel containing M. piperita essential oil as a repellent and antibacterial agent was more potent than the nanogel containing F. vulgare essential oil. Its completely protected time against Anopheles stephensi, the main malaria mosquito vector, was 120 ± 8 min. Moreover, the growth of Escherichia coli and Staphylococcus aureus after treatment with 5000 µg/mL of nanogel containing M. piperita essential oil was reduced by 100 and 65%, respectively. Considering natural constituents, a straightforward preparation method, and high efficacy, the nanogel containing M. piperita essential oil could be introduced for further investigation against other mosquitoes and bacterial species.

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“…ZMSLN was prepared according to our described high-pressure Homogenizer method [ 17 ]. ZMEO (1% v/v) was first dissolved in stearic acid 4% w/v (temperature = 85 °C) and a hot span 60 2% w/v (lipophilic surfactant).…”

Section: Methodsmentioning

confidence: 99%

High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines

Valizadeh

Khaleghi

Roozitalab

et al. 2021

BMC Pharmacol Toxicol

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Background The cancer burden is rising rapidly worldwide, and it annually causes about 8.8 million deaths worldwide. Due to chemical drugs’ side effects and the emergence of resistance, the development of new green drugs has received much attention. We aimed to investigate whether solid-lipid nanoparticles containing essential oil of Zataria multiflora (ZMSLN) enhanced the anticancer efficacy of the essential oil against breast cancer (MDA-MB-468) and melanoma (A-375) cells. Results ZMSLN was prepared by the high-pressure homogenizer method; particle size 176 ± 8 nm, polydispersity index 0.22 ± 0.1, entrapment efficiency 67 ± 5%. The essential oil showed a dose-dependent antiproliferative effect on MDA-MB-468 and A-375 cells at all examined concentrations (75, 150, 300, 600, and 1200 μg/mL). Interestingly, after treating both cells with 75 μg/mL of ZMSLN, their viabilities were reduced to under 13%. Conclusion The finding showed that ZMSLN had a distinct antiproliferative efficacy; it could thus be considered a green anticancer candidate for further in vivo and in vivo studies.

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Solid-lipid nanoparticles (SLN)s containing Zataria multiflora essential oil with no-cytotoxicity and potent repellent activity against Anopheles stephensi

Cited by 40 publications

References 27 publications

A Nanoliposomal Gel Containing Cinnamomum zeylanicum Essential Oil with Effective Repellent against the Main Malaria Vector Anopheles stephensi

A Nanoliposomal Gel Containing Cinnamomum zeylanicum Essential Oil with Effective Repellent against the Main Malaria Vector Anopheles stephensi

Nanogels Containing Foeniculum vulgare Mill. and Mentha piperita L. Essential Oils: Mosquitoes’ Repellent Activity and Antibacterial Effect

High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines

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