Solid particulates of drug-β-cyclodextrin inclusion complexes directly prepared by a spray-drying technique

Lin, Shan‐Yang; Kao, Yuh-Horng

doi:10.1016/0378-5173(89)90022-7

Cited by 87 publications

(6 citation statements)

References 16 publications

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“…The dehydration effect in the RV product with β-CD is shifted to lower temperature 70–100 °C, and appeared to be of lower intensity because of the dehydration due to the RV treatment. The disappearance of PX endothermic melting peak in the thermogram of the RV product can be attributed to the inclusion of drug in the cyclodextrin cavity [23]. DSC curve of the Me-β-CD complex showed, for each curve, the solvent loss in a range temperature between 70–110 °C.…”

Section: Resultsmentioning

confidence: 99%

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

et al. 2019

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In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.

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Section: Resultsmentioning

confidence: 99%

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

et al. 2019

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“…For comparison, chitosan nanoparticles obtained by Ngan et al [45] were also spherical. Structures that look like deflated balloons have been observed with different wall materials, such as cyclodextrin [46], OSA-starch [47], maltodextrin or gum Arabic [48,49]. As far as freeze-dried particles are concerned, various shapes have been described, which are attributed to the different shapes of water crystals before water sublimation in the lyophilization process.…”

Section: Preparation Of Particlesmentioning

confidence: 99%

Polysaccharide Matrices for the Encapsulation of Tetrahydrocurcumin—Potential Application as Biopesticide against Fusarium graminearum

Loron

Navikaitė-Šnipaitienė

Rosliuk

et al. 2021

Molecules

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Cereals are subject to contamination by pathogenic fungi, which damage grains and threaten public health with their mycotoxins. Fusarium graminearum and its mycotoxins, trichothecenes B (TCTBs), are especially targeted in this study. Recently, the increased public and political awareness concerning environmental issues tends to limit the use of traditional fungicides against these pathogens in favor of eco-friendlier alternatives. This study focuses on the development of biofungicides based on the encapsulation of a curcumin derivative, tetrahydrocurcumin (THC), in polysaccharide matrices. Starch octenylsuccinate (OSA-starch) and chitosan have been chosen since they are generally recognized as safe. THC has been successfully trapped into particles obtained through a spray-drying or freeze-drying processes. The particles present different properties, as revealed by visual observations and scanning electron microscopy. They are also different in terms of the amount and the release of encapsulated THC. Although freeze-dried OSA-starch has better trapped THC, it seems less able to protect the phenolic compound than spray-dried particles. Chitosan particles, both spray-dried and lyophilized, have shown promising antifungal properties. The IC50 of THC-loaded spray-dried chitosan particles is as low as 0.6 ± 0.3 g/L. These particles have also significantly decreased the accumulation of TCTBs by 39%.

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“…The increase of DSL solubility was absolutely associated with the extent of the interactive relation of the active agent with HP-β-CD according to preparation method. The remarkable increment of the aqueous solubility that occurred with FD and SD complexes has been ascertained to the inclusion complexation with high energetic amorphous status/decrease of post-complexation crystallinity [7,28]. SEM is a principle technique for assessing quantitatively alterations in particle size and the surface morphology of materials, such as inclusion complexes [12].…”

Section: Dls Content Yield and Aqueous Solubilitymentioning

confidence: 99%

Host-guest inclusion complex of desloratadine with 2-(hydroxy)propyl-?-cyclodextrin (HP-?-CD): Preparation, binding behaviors and dissolution properties

Kırımlıoğlu¹

2020

jrp

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Desloratadine (DSL) is an anti-allergic agent that diminishes nasal and non-nasal allergic marks of seasonal allergic rhinitis. However, its efficiency of DSL is restricted with its low dissolution rate and aqueous solubility. The influence of 2-(hydroxy)propyl-β-cyclodextrin (HP-β-CD) on the DSL solubility was evaluated in respect of the phase solubility method. Following the formulation of inclusion complexes of DSL and HP-β-CD with various strategies (freeze-drying, spray-drying and kneading) (FD, SD and KN), compounds were investigated to evaluate the possibility of altering the physicochemical properties (solubility, release, stability, morphology) of DSL after complexation that are critical for subsequent formulation studies including the complexes prepared. Changes in DSC thermograms, FT-IR spectra and NMR spectra confirmed the constitution of a DSL-HP-β-CD complexes. In vitro release from inclusion complexes was compared to pure DSL by dialysis method. It was found that solubility enhancements of DSL-HP-β-CD complexes relies on the sort of the formulation technique. Higher release of DSL from complexes compared to pure DSL was ascribed to the interactive relations between HP-β-CD and DSL, high energetic amorphous status and inclusion complex constitution.

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Solid particulates of drug-β-cyclodextrin inclusion complexes directly prepared by a spray-drying technique

Cited by 87 publications

References 16 publications

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

Polysaccharide Matrices for the Encapsulation of Tetrahydrocurcumin—Potential Application as Biopesticide against Fusarium graminearum

Host-guest inclusion complex of desloratadine with 2-(hydroxy)propyl-?-cyclodextrin (HP-?-CD): Preparation, binding behaviors and dissolution properties

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