Solid-phase extraction of acetazolamide from biological fluids and subsequent analysis by high-performance liquid chromatography

Determination of acetazolamide by graphene paste electrode

“…About 80% of the drug is excreted by tubular secretion of the anionic species, and 70-90% of the administered dose is recovered unchanged within 24 h [28]. The determination of ACZ in biological fluids is usually carried out by sol-gel optical biosensor [29], polarography [30], enzymatic assay [31], electron-capture GLC [32], molecular imprinted polymer (MIP) [33], carbon paste electrode modified with gold nanoparticle [34] and high-performance liquid chromatography [35][36][37][38][39]. However, most of the above methods require several time consuming manipulation steps, sophisticated instruments and special training.…”

The clinical value of salivary biomarkers for periodontal disease

“…Numerous drugs are detectible in oral fluid, and can even be quantified in saliva as a viable substitute for testing in blood, and, as a result, salivary diagnostic technology is currently utilized to test for drugs of abuse, such as cocaine (50, 94), methamphetamines (44, 93) and opiates (20). Additionally, testing of saliva can also be used for therapeutic monitoring of drugs, such as digoxin (19, 108), methadone (17) and some anticonvulsants (34).…”

Tb -4'carboxybenzo-18crown-6-ether Photo Probe or the Assessment of Nalbuphin HCl in Serum and Pharmaceutical Formulations

“…Luminescent photo probes lanthanide complexes have more advantages over the present ones; photo probe has high stability and durability. The photo probe can provide constant signal response for 2 years which is 24-fold better stability compared to the life time warranted for the chromatographic and colorimetric methods [6][7][8][9][10][11][12][13][14]. Photo probe is stable over all measurements which prevent the source of error in the measurement process and it gives a low standard deviation values.…”