Solid-phase synthesis of oligoethers: soluble polymer model studies

Tailored Polymer‐Supported Templates in Dynamic Combinatorial Libraries: Simultaneous Selection, Amplification and Isolation of Synthetic Receptors

“…Template attachment to pre-formed polymer resins: In the next step the functionalised protected quinine 1.6 and quinidine 2.4 were attached via an ether linkage to the in-house prepared VBC-containing resins (Scheme 3). [50,51,53,75] The use of microwave reactor vessels proved advantageous for small scale reactions, while for larger scale reactions A C H T U N G T R E N N U N G (>500 mg) a classical experimental set up [76][77][78] using a threenecked, round-bottomed flask with nitrogen inlet, condenser and mechanical stirrer was a better choice. Cleavage of the tert-butyldimethylsilyl ether was carried out at room temperature in sealed glass vials on flatbed rollers for 24 h.…”

Preparation, structure and morphology of polymer supports

“…Nevertheless there are situations where linear soluble polymers can be extremely useful and a key factor in this is that chemical reactions performed on such polymers can be a d for polystyrene and styrene-divinylbenzene copolymers is ~17-18 (MPa) 0.5 monitored by, for example, high resolution solution phase 1 H and 13 C NMR spectroscopy. 15 Though the resonances due to backbone protons are usually broadened, signals arising from mobile groups in the sidechain are often as sharp as resonances from analogous low molecular weight groups in isotropic solution. Recently, however, considerable advances have also been made in 1 H and 13 C NMR analysis of crosslinked polymers 16 (see later).…”

Polymer-supported synthesis

“…As well as particular peptides, generally with some potential biological activity associated with them, interest has grown in synthesising glycopeptides. The problems of extending the concept to oligoether synthesis, which at first sight seems simple, have also been highlighted [82].…”