Solid phase wax coating of N-acetylcysteine (NAC) to decrease its solubility profile as a ready to mix supplement

Abstract

N-Acetylcysteine (NAC) has significant health benefits. Wax coating is applied to granules, crystals, and powdered NAC to make it more palatable by delaying its release in water.

Solid–Liquid Equilibrium Modeling and Analysis of Acetylcysteine in 12 Pure Solvents

“…However, the solubility of acetylcysteine in various solvents has not been systematically investigated. 2 On this basis, the present work assessed the solubility of acetylcysteine in 12 pure solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, dimethylformamide, formamide, ethylene glycol, dimethylacetamide, and dimethyl sulfoxide) using a dynamic laser technique at temperatures ranging from 278.15 to 323.15 K under atmospheric pressure. The resulting solubility data were correlated using the modified Apelblat equation, the λh equation, the Wilson model, and the NRTL model.…”

“…The optimization of this recrystallization step requires knowledge concerning the solubility of acetylcysteine in specific solvents. However, the solubility of acetylcysteine in various solvents has not been systematically investigated …”