Solid pseudopapillary neoplasm–Case report of a rare pancreatic tumor

Branco, Cláudio; Vilaça, Sónia; Falcão, Joaquim

doi:10.1016/j.ijscr.2017.02.049

Cited by 24 publications

(29 citation statements)

References 20 publications

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“…SPT has a complex immune profile. In previous studies respective percentages of patients demonstrated positive staining with NSE (93%), vimentin (90%), chromogranin A, cytokeratin, and synaptophysin [2, 8]. In another study performed with 11 pediatric patients with SPT, respective percentages of patients displayed positive staining with NSE (36%), chromogranin A (91%) [8].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of childhood pancreas solid pseudopapillary tumors

Özcan

Arslanoglu

Ünal

et al. 2017

North Clin Istanbul

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OBJECTIVE:Solid pseudopapillary tumor (SPT) of the pancreas is an extremely rare primary tumor in the pediatric age group. It has a low malignant potential and the prognosis is good if radical resection of the tumor is performed. Local recurrence and distant metastasis has only rarely been reported following incomplete resection.METHODS:A retrospective review of the medical records of 6 patients diagnosed as SPT according to a histopathological examination at the Children’s Hospital of Erciyes University School of Medicine between 2010 and 2017 was performed. Demographic characteristics, tumor localization and size, diagnostic method, immunohistochemical staining features, and medical and surgical treatments employed were recorded.RESULTS:There were 4 girls and 2 boys with the diagnosis of SPT included in this study. The mean age of the patients was 14 years (min-max: 13–16 years). The most common presenting complaint was abdominal pain. The mass lesion was at the head of the pancreas in 3 cases (50%) and the tail of the pancreas in the remaining 3 patients (50%). A Whipple procedure was performed in 3 cases, a distal pancreatectomy in 1, a distal pancreatectomy plus splenectomy in 1, and a subtotal pancreatectomy in 1patient. Immunohistochemistry revealed positive staining for beta-catenin, keratin, CD56, vimentin, and CD10 in all cases.CONCLUSION:SPT is a rarely seen pancreatic mass with low rate of malignancy. Diagnosis may be delayed due to its asymptomatic nature in most cases and a lack of descriptive symptoms. The survival rate is quite high after radical resection.

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Section: Discussionmentioning

confidence: 99%

“…In all age groups they constitute 2–3% of all primary pancreatic tumors [1]. They are more frequently seen in the second, and third decades of life, and in female children [2]. It was firstly defined by Frantz in the year 1959, and it was termed as papillary cystic tumor, solid cystic tumor, Frantz’s tumor [3].…”

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confidence: 99%

Evaluation of childhood pancreas solid pseudopapillary tumors

Özcan

Arslanoglu

Ünal

et al. 2017

North Clin Istanbul

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“…Con respecto al uso de ecoendoscopía, la literatura menciona que el diagnóstico definitivo es difícil por las siguientes razones: En primer lugar, los hallazgos de la ecoendoscopia son complejos y, a menudo, variables según el grado de degeneración hemorrágica; en segundo lugar, la aparición de tumores sólidos pseudopapilares en pacientes varones tiende a ser una lesión pequeña y sólida sin componente quístico, y los tumores pequeños con frecuencia tienden a presentarse como masas sólidas puras con un margen agudo; en tercer lugar, los hallazgos de la Eco endoscopia de los tumores pseudopapilares de <3 centímetros parecen diferir de aquellos que son > 3 centímetros. Proponen que el patrón de eco interno que podría ayudar a diferenciar sobre todo con los tumores neuroendocrinos, es el patrón heterogéneo prominente (9,10) .…”

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Tumor sólido pseudopapilar de páncreas: Tumor de Frantz

et al. 2018

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El tumor pseudopapilar de páncreas, también conocido como tumor de Frantz, es una enfermedad muy rara en nuestro medio, comprende menos del 3 % de los tumores pancreáticos (1). Su etiología es desconocida, y su incidencia se observa en mujeres jóvenes con predominancia de la tercera década de la vida. Presentamos el caso de una mujer de 23 años que ingresa por epigastralgia urente desde hace 3 meses, además de llenura precoz. Al examen presenta dolor a la palpación profunda. Cuenta con perfil bioquímico, hepático, marcadores tumorales dentro de valores normales, la tomografía espiral multicorte (TEM) abdomino-pélvica reporta lesión neoformativa sólida quística de morfología redondeada de bordes bien definidos, la patología confirma tumor sólido pseudopapilar de páncreas. La paciente se somete a resección de tumor, con evolución favorable.

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“…Unusual symptoms also described are vomiting, hematemesis, lack of appetite and weight loss 7 . Although rare, reported cases in the world has increased 3,8 . In the national literature, it is possible to find relevant case series with 4 to 14 patients 9,10 .…”

Section: Discussionmentioning

confidence: 99%

Frantz’s tumor in a female patient with diarrhea: case report of a rare pancreatic neoplasm

Farias

Maciel

Araújo

et al. 2018

Rev. Med. (São Paulo)

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RESUMO:O tumor pseudopapilar sólido, também conhecido como tumor de Frantz, é um tumor raro do pâncreas. Relatamos o caso de uma paciente de 25 anos com dor abdominal, febre, diarréia e perda de peso.TC de abdome com contraste revelou pâncreas alargado com lesão hipodensa de aparência nodular e calcificações periféricas. Foi decidido realizar pancreatectomia subtotal com linfadenectomia e optou-se pela esplenectomia com biópsia hepática intra-operatória. O anatomopatológico da ressecção cirúrgica do tumor pancreático revelou tumor pseudopapilar sólido compatível com o tumor de Frantz. A imuno-histoquímica confirmou os achados histopatológicos. Ela evoluiu com fístula pancreática e pancreatite resolvida após 15 dias. Atualmente, está sendo acompanhada ambulatorialmente em nosso serviço com remissão completa dos sintomas.Descritores: Neoplasias pancreáticas/terapia; Dor abdominal; Diarréia; Perda de peso.ABSTRACT: Solid pseudopapillary tumor, also known as frantz tumor, is a rare tumor of the pancreas. We report a case of 25-yearold female patient with abdominal pain, fever, diarrhea and weight loss. Contrast abdominal CT showed enlarged pancreas with a hypodense lesion of nodular appearance and peripheral calcifications.It was decided to perform subtotal pancreatectomy with lymphadenectomy, and opted for splenectomy and intraoperative liver biopsy. The pathology of surgical resection of the pancreatic tumor showed solid pseudopapillary tumor compatible with Frantz's tumor. Immunohistochemistry confirmed histopathological findings. She evolved with pancreatic fistula and pancreatitis resolved after 15 days. Currently, it is being followed up in our service with complete remission of symptoms.

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Solid pseudopapillary neoplasm–Case report of a rare pancreatic tumor

Cited by 24 publications

References 20 publications

Evaluation of childhood pancreas solid pseudopapillary tumors

Evaluation of childhood pancreas solid pseudopapillary tumors

Tumor sólido pseudopapilar de páncreas: Tumor de Frantz

Frantz’s tumor in a female patient with diarrhea: case report of a rare pancreatic neoplasm

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