Solid Pseudopapillary Neoplasm of the Pancreas: Experience of a Tertiary Hospital

Abstract

Background: Solid pseudopapillary neoplasm of pancreas is a rare tumor, predominantly affecting young women, usually with a favorable prognosis. Methods: We present a retrospective observational case-series study of eight patients diagnosed and treated in a dedicated hepatobiliary and pancreatic unit, describing the clinicopathological and immunohistochemical features. Results: seven patients were female, with a mean age of 31 years; the most frequently performed procedure was distal pancreatectomy in six cases. The lesions were well defined, with solid or mixed aspects, with 57,6 mm average size. Average follow-up is 88 months without disease recurrence or mortality records during that period. Conclusion: Given the rarity of these neoplasms, its orientation should be made only in referral centers, with multidisciplinary teams committed to pancreatic pathology.

Solid Pseudopapillary Neoplasm of the Pancreas: Unfolding an Intriguing Condition

“…SPNs typically show nuclear/cytoplasmic immunoreactivity for β-catenin, very characteristic immunoreactivity for CD99 (dotlike paranuclear expression) and an aberrant expression of E-cadherin (positivity for antibodies against the cytoplasmic domain tumor but negativity for antibodies against extracellular fragments), while being negative for acinar cell markers (trypsin and BCL10) as well as for neuroendocrine marker chromogranin. Alternatively, we present the panel detailed in the paper by Bouça-Machado et al [37] that illustrates a case series from our institution: PR (positivity), CD56 (positivity), vimentin (positivity), CD10 (positivity), β-catenin (nuclear positivity), synaptophysin (focal positivity), α1-antitrypsin (focal positivity), and chromogranin (negativity).…”