Solid-state fluorodensitometric quantitation of arylnaphthalene lignan lactones of Cleistanthus collinus

Annapoorani, K.S.; Damodaran, C.; Sekharan, P. Chandra

doi:10.1016/s0021-9673(01)96081-9

Cited by 11 publications

(3 citation statements)

References 7 publications

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“…[68–71] Other techniques that have been used for detection of toxin in blood and urine include high performance liquid chromatography (HPLC), spectrophotometry and thin-layer chromatography. [3237–397273]…”

Section: Introductionmentioning

confidence: 99%

Cleistanthus collinus poisoning

Chrispal

2012

J Emerg Trauma Shock

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Cleistanthus collinus, a toxic shrub, is used for deliberate self-harm in rural South India. MEDLINE (PUBMED) and Google were searched for published papers using the search/ MeSH terms “Cleistanthus collinus,” “Euphorbiaceae,” “Diphyllin,” “Cleistanthin A,” Cleistanthin B” and “Oduvanthalai.” Non-indexed journals and abstracts were searched by tracing citations in published papers. The toxic principles in the leaf include arylnaphthalene lignan lactones — Diphyllin and its glycoside derivatives Cleistanthin A and B. Toxin effect in animal models demonstrate neuromuscular blockade with muscle weakness, distal renal tubular acidosis (dRTA) and type 2 respiratory failure with conflicting evidence of cardiac involvement. Studies suggest a likely inhibition of thiol/thiol enzymes by the lignan-lactones, depletion of glutathione and ATPases in tissues. V-type H+ ATPase inhibition in the renal tubule has been demonstrated. Mortality occurs in up to 40% of C. collinus poisonings. Human toxicity results in renal tubular dysfunction, commonly dRTA, with resultant hypokalemia and normal anion gap metabolic acidosis. Aggressive management of these metabolic derangements is crucial. Acute respiratory distress syndrome (ARDS) is seen in severe cases. Cardiac rhythm abnormalities have been demonstrated in a number of clinical studies, though the role of temporary cardiac pacemakers in reducing mortality is uncertain. Consumption of decoctions of C. collinus leaves, hypokalemia, renal failure, severe metabolic acidosis, ARDS and cardiac arrhythmias occur in severe poisonings and predict mortality. Further study is essential to delineate mechanisms of organ injury and interventions, including antidotes, which will reduce mortality.

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Section: Introductionmentioning

confidence: 99%

Cleistanthus collinus poisoning

Chrispal

2012

J Emerg Trauma Shock

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“…Finally, a fluorodensitometric method for the quantitative detection of the biologically important arylnaphthalene lignan lactones has been developed. 159 6 Hybrid Lignans A significant number of natural compounds has been purified and shown to have structures that are characterized by coupling between an Ar-C, unit (as in a lignan) and a unit such as a flavonoid or a xanthone. Such compounds, of mixed biogenetic origin, have been variously described, as ' lignoids ' or ' lignocompounds ', or, for example, flavonolignans.…”

Section: Activity Reportsmentioning

confidence: 99%

Lignans, neolignans, and related compounds

Whiting¹

1987

Nat. Prod. Rep.

103

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“…[ 3 4 5 6 ] The other active principles in C. collinus leaves include diphyllin, collinusin and all the compounds are arylnaphthalene lignin lactones. [ 7 8 9 10 11 12 13 ] More than 25 compounds are derived from the plant, but these two compounds are reported to be the major compounds. The compounds are evaluated for pharmacological activities like diuretic activity, anticancer activity, neuromuscular blocking property.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B

Priyadharsini¹,

Parasuraman²,

Raveendran³

2014

J Basic Clin Pharma

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Hypertension was induced in male Sprague Dawley rats with twice weekly administration of deoxycorticosterone acetate (DOCA) salt (20 mg/kg s.c) for 4 weeks. They were divided into eight groups of six animals each viz., hypertensive control, standard (prazosin 1 mg/kg), cleistanthin A 12.5, 25, 50 mg/kg and cleistanthin B 12.5, 25 mg/kg, and 50 mg/kg. One more group served as normal control. The hypertension was induced in 4 weeks, and the animals were given assigned treatment in 5th week. The alteration in blood pressure (BP) was recorded weekly using a rodent noninvasive blood pressure system. At the end of the experiment alpha-adrenergic receptor response of drugs like adrenaline, nor adrenaline, dopamine (doses 1 μg and 2 μg) was recorded invasively. Two-way repeated measures ANOVA followed by Bonferroni post-hoc test was used to analyze the data. The systolic BP and diastolic BP of test groups rose to a higher level after DOCA administration and fell to the normal range (P < 0.05) following the administration of cleistanthins A and B. There were no differences in the weekly heart rate among the groups. In the test group animals pretreated with prazosin and cleistanthins, adrenaline, noradrenaline and dopamine failed to raise the mean arterial pressure and the end-diastolic pressure from baseline (P > 0.05) cleistanthins A and B exert a significant antihypertensive effect through alpha-adrenergic receptor blockade similar to prazosin.

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Solid-state fluorodensitometric quantitation of arylnaphthalene lignan lactones of Cleistanthus collinus

Cited by 11 publications

References 7 publications

Cleistanthus collinus poisoning

Cleistanthus collinus poisoning

Lignans, neolignans, and related compounds

Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B

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