2006
DOI: 10.1021/cm061551c
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Solid-State NMR Study of Ibuprofen Confined in MCM-41 Material

Abstract: Ibuprofen (an anti-inflammatory drug that is a crystalline solid at ambient temperature) has been encapsulated in MCM-41 silica matrices with different pore diameters (35 and 116 Å). Its behavior has been investigated by magic angle spinning (MAS) 1H, 13C, and 29Si solid-state NMR spectroscopy at ambient and low temperature. This study reveals an original physical state of the drug in such materials. At ambient temperature, ibuprofen is not in a solid state (crystalline or amorphous) and is extremely mobile in… Show more

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Cited by 248 publications
(271 citation statements)
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“…It was shown through 2D 1 H- 29 Si HetCor experiments that this signal corresponds to protons close to silica sites. 30 This specific signal is also observed for various MCM-41-encapsulated carboxylic acids samples and in particular in the case of benzoic acid 31 that is often considered as a model molecule of ibuprofen due to the presence of common chemical moieties (phenyl ring and carboxylic acid group).…”
Section: H Mas Nmr Spectra Of Ibu and Ibu@mcm Together With The Resonmentioning
confidence: 68%
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“…It was shown through 2D 1 H- 29 Si HetCor experiments that this signal corresponds to protons close to silica sites. 30 This specific signal is also observed for various MCM-41-encapsulated carboxylic acids samples and in particular in the case of benzoic acid 31 that is often considered as a model molecule of ibuprofen due to the presence of common chemical moieties (phenyl ring and carboxylic acid group).…”
Section: H Mas Nmr Spectra Of Ibu and Ibu@mcm Together With The Resonmentioning
confidence: 68%
“…Below the glass transition (Tg) of MCM-41 encapsulated ibuprofen (Tg = -50°C), the resonance of the COOH moiety is then observed at ( 1 H) = 15 ppm. 30 Another specific resonance is observed in the 1 H MAS NMR spectrum of MCM-41 encapsulated ibuprofen at Tamb and not precisely assigned in the literature until now (asterisk in Figure 1). This resonance is broad and located at 6.7 ppm.…”
Section: H Mas Nmr Spectra Of Ibu and Ibu@mcm Together With The Resonmentioning
confidence: 87%
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“…isobutyric acid) liquids, the phase transition temperatures can be modied when the liquid is entrapped inside a porous matrix. This so-called connement effect has also been observed for encapsulated organic solids, including anti-inammatory APIs, [8][9][10] where the particle structure and even the physical state of the molecules are different to those in the bulk material. The connement effect on melting and glass transition temperatures mainly depends on the pore size and the relative strength between the guest/guest and host/guest interactions.…”
mentioning
confidence: 76%