Solid state of inhalable high dose powders

Adhikari, Bishal Raj; Gordon, Keith C.; Das, Shyamal C.

doi:10.1016/j.addr.2022.114468

Cited by 10 publications

(6 citation statements)

References 151 publications

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“…Bottom-up techniques include spray freeze drying and supercritical fluids [ 133 ]. The chosen preparation technique affects the solid state of the powder, which can potentially modulate atomization and atomization stability [ 134 ]. The spray freeze-drying technique has been used to create inhalable particles of nucleic acid medications, influenza vaccinations, protein-peptide pharmaceuticals, and small molecules such as Technosphere® and PulmoSphereTM.…”

Section: Delivery Devices and Processing Technology For Pulmonary Dru...mentioning

confidence: 99%

Pulmonary inhalation for disease treatment: Basic research and clinical translations

Wang,

Yang

et al. 2024

Materials Today Bio

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Section: Delivery Devices and Processing Technology For Pulmonary Dru...mentioning

confidence: 99%

Pulmonary inhalation for disease treatment: Basic research and clinical translations

Wang,

Yang

et al. 2024

Materials Today Bio

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“…17 Crystalline particles offer the merits of better chemical and physical stability. 76,77 TiO 2 has been found in nature under three crystal structures: rutile, anatase and plagioclase. Plagioclase is the least stable, while anatase and rutile are more stable.…”

Section: Ac Breakdown Voltage (Ac Bdv)mentioning

confidence: 99%

Modification of insulating oils and oil-based titanium dioxide nanofluids for transformers: a review

Zhang¹,

Zuo²,

Cai³

et al. 2023

Phys. Chem. Chem. Phys.

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“…Thermogravimetric analysis of the powders showed that all the powders had a low water content of <1.9% w/w (Table 2). Such low water content for inhalable powders is desirable as moisture present in the formulation can lead to particle-sticking with or without transformation, which can adversely affect the aerosol performance of the powders [14].…”

Section: Thermal Analysismentioning

confidence: 99%

“…However, leucine improved the FPF of kanamycin from 48 to 73% when 5% leucine was used [22]. Such discrepancy in aerosolization enhancement behavior of amino acids is assumed to fragment from the multitude of factors such as particle size, density, surface asperity, surface enrichment, and relative intrinsic cohesive property of drugs/excipients used, which can dictate the aerosol performance of spray-dried particles [2,14,23,24]. to fragment from the multitude of factors such as particle size, density, surface asperity, surface enrichment, and relative intrinsic cohesive property of drugs/excipients used, which can dictate the aerosol performance of spray-dried particles [2,14,23,24].…”

Section: Aerosol Performance Of the Powdersmentioning

confidence: 99%

Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders

Adhikari

Das

2022

Pharmaceutics

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Soluplus is a polymer that has been explored to prepare nanocomposites for pulmonary drug delivery and is non-toxic. However, its aerosolization attributes when spray-dried have not been investigated. Hence, this work aimed to investigate the aerosol performance of soluplus-based spray-dried powders. In addition, the potential use of leucine to improve the aerosolization of such particles was also investigated by including leucine at 10 or 20% w/w. 4% w/w salbutamol was used as a model drug in all the formulations primarily to aid quantification during aerosolization evaluation and for assessing the interaction between the drug and soluplus using infrared spectroscopy with the multivariate analysis approach of principal component analysis (PCA). Three formulations (4% salbutamol/96% soluplus, 4% salbutamol/86% soluplus/10% leucine, 4% salbutamol/76% soluplus/20% leucine) were prepared. The formulations were characterized in terms of solid-state, water content, particle size/morphology, and aerosolization. Similarly, two additional formulations (14% salbutamol/86% soluplus and 24% salbutamol/76% soluplus) were prepared to assess potential non-covalent interactions between salbutamol and soluplus. The formulations with only salbutamol and soluplus were amorphous, as evident from X-ray diffraction. Leucine was crystalline in the formulations. All the spray-dried formulations were irregular spheres with surface corrugation. The 96% soluplus powder showed an emitted fraction (EF) and fine particles fraction (FPF) of 91.9 and 49.8%, respectively. The inclusion of leucine at 10% did not increase the EF; however, an increase in FPF (69.7%) was achieved with 20% leucine. PCA of the infrared spectra suggested potential non-covalent interactions between salbutamol and soluplus. It hinted at the potential involvement of ketone groups of the excipient. This study concludes that soluplus-based spray-dried powder with or without leucine can potentially be utilized for pulmonary drug delivery. In addition, PCA can effectively be utilized in assessing interactions and overcoming limitations associated with visual assessment of the spectra of such formulations.

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Solid state of inhalable high dose powders

Cited by 10 publications

References 151 publications

Pulmonary inhalation for disease treatment: Basic research and clinical translations

Pulmonary inhalation for disease treatment: Basic research and clinical translations

Modification of insulating oils and oil-based titanium dioxide nanofluids for transformers: a review

Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders

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