Solid state reactions of nitrogenous heterocyclic compounds (II)

Bis- and Trisindolylmethanes (BIMs and TIMs)

“…For instance, when R = H, 33 was obtained in 35.2% yield and for R = CH 3 in 33.5% yield (Scheme ). The report demonstrates that the solid-state reaction exhibits higher selectivities and yields than the corresponding reaction in solution …”

“…The report demonstrates that the solid-state reaction exhibits higher selectivities and yields than the corresponding reaction in solution. 293 Although the synthesis of BIM 36 had been reported by Russian chemists many years ago, it was also isolated in 30% yield from 35 and indole in the presence of boron trifluoride etherate (Scheme 14). 294 The intermediate 35 has been obtained in a Friedel-Crafts reaction of benzoin 34 and indole.…”

An Efficient One‐pot Synthesis of Pyrazolone Derivatives Promoted by Acidic Ionic Liquid

“…The electrocatalytic procedure and solid-state condensation procedure were also applied to the preparation of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols). [9][10][11][12] So far, intensive work has been focused on developing efficient catalytic systems for conforming to the concept of green chemistry. Recently, Niknam et al reported a reaction for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) through the condensation of aldehydes with 3-methyl-1-phenyl-5-pyrazolone in the presence of silica-bonded S-sulfonic acid.…”