Solid/Trabecular Variant of Papillary Thyroid Carcinoma

Ohashi, Ryuji

doi:10.1007/978-981-13-1897-9_31

Cited by 1 publication

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“…These reports along with our observation collectively show that cohesive syncytial fragments, a trabecular pattern, accompanied by some discohesiveness, in a clean background without necrotic debris are characteristic of SVPTC ( Fig. 1F) [19]. A study by Guleria et al found that the presence of solid fragments and lack of true papillae are helpful in differentiating SVPTC from CPTC [20].…”

Section: Cytological Featuressupporting

confidence: 81%

Solid variant of papillary thyroid carcinoma: an under-recognized entity

Ohashi

2020

Endocr J

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Solid variant of papillary thyroid carcinoma (SVPTC) is a rare morphological variant of papillary thyroid carcinoma (PTC). SVPTC is histologically characterized by predominant solid, trabecular and insular nests of tumor cells while cytological features of PTC such as nuclear grooves and nuclear inclusions are preserved. In fine needle aspiration cytology smears, tumor cells of SVPTC may be presented in cohesive, syncytial or trabecular clusters accompanied by some discohesiveness in the absence of necrosis. Although SVPTC and poorly differentiated thyroid carcinoma (PDTC) share similar histological findings of solid nests, SVPTC can be differentiated from PDTC in the lack of tumor necrosis, severe nuclear atypia, and a higher mitotic index. Immunohistochemical expression of CK19 and HBME-1, common markers of PTC, is decreased in solid nests of SVPTC. In pediatric patients exposed to radiation after the Chernobyl nuclear accident, there was a higher prevalence of SVPTC with RET/PTC3 type rearrangement. BRAF mutations are also reported in a small number of adult patients with SVPTC without any prior radiation exposure. Patients with SVPTC may have a slightly higher incidence of metastasis and recurrence of the tumor compared to conventional PTC, although overall survival rate is comparable. In this article, the current knowledge of SVPTC will be reviewed and discussed with an emphasis on the histopathological feature.

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Section: Cytological Featuressupporting

confidence: 81%