Solid Tumor Metastases to the Pancreas Diagnosed Using Fine-Needle Aspiration

Abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>Solid tumor metastases to the pancreas are rare, and only limited literature on the topic is available. In this retrospective study, we reviewed 107 cases of solid tumor metastases to the pancreas diagnosed by fine-needle aspiration (FNA) from 2005 to 2019.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Information including the patients’ clinical histories, radiologic and pathologic findings, treatments, and follow-up were collected.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>The mean age of the patients was 62.4 years. The mean tumor size was 2.64 cm with even distribution throughout the pancreas (head, neck and body, and tail). The most common primary site was the kidney, followed by the lung, skin, and breast and the gynecologic, gastrointestinal, and genitourinary tracts. The most common tumor type was carcinoma, followed by melanoma and sarcoma. In comparison to patients with nonkidney primary cancers, those with primary renal cell carcinoma had a longer median interval between primary diagnosis and metastasis (8.5 vs 4.0 years; P &amp;lt; .01), less often had metastasis outside the pancreas (38% vs 74%; P &amp;lt; .01), and had a significantly longer 5-year survival rate (65.7% vs 24.8%; P &amp;lt; .01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>FNA plays a crucial role in diagnosing metastases to the pancreas. Metastases originating from kidney and nonkidney primary tumors have distinct clinicopathologic features and prognoses.</jats:p> </jats:sec>

An exceptionally rare case of metastatic high‐grade urothelial carcinoma of the renal pelvis to the pancreas diagnosed on endoscopic ultrasound‐guided fine‐needle aspiration: A diagnostic challenge

“…Carson HJ (total cases; 13) 24 Volmar KE (total cases; 20) 25 Adsay NV (total cases; 81) 11 Smith AL (total cases; 22) 12 Hajj II (total cases; 49) 21 Waters L (total cases; 66) 26 Nakamura E (total cases; 103) 27 Hou T (total cases; 107) 1 Ioakim KJ (total cases; 7) 8 Layfield LJ (total cases; 17) 3 Abbreviations: Ca, carcinoma; GIST, gastrointestinal stromal tumor; LMS, leiomyosarcoma; NOS, not otherwise specified; SCC, squamous cell carcinoma; Small CC, small cell carcinoma.…”

“…Metastases to the pancreas are mostly asymptomatic and can be detected by examinations such as computed tomography and magnetic resonance imaging. 1 Tumor that metastasizes to the pancreas includes kidney, lung, breast, melanoma, colorectal cancers, and sarcomas. Renal cell carcinomas have been reported in increasing numbers in recent years.…”

“…2 Clear cell renal cell carcinoma (CCRCC) is the most common epithelial tumor that metastasizes to the pancreas. 1 The frequency and origin of organs that metastasize to the pancreas vary according to the published series and populations. In some studies, lung carcinomas predominantly metastasize to the pancreas.…”

“…Metastasis of solid tumors in the pancreas is generally rare and accounts for approximately 2%–5% of all pancreatic malignancies. Metastases to the pancreas are mostly asymptomatic and can be detected by examinations such as computed tomography and magnetic resonance imaging 1 . Tumor that metastasizes to the pancreas includes kidney, lung, breast, melanoma, colorectal cancers, and sarcomas.…”

“…Renal cell carcinomas have been reported in increasing numbers in recent years 2 . Clear cell renal cell carcinoma (CCRCC) is the most common epithelial tumor that metastasizes to the pancreas 1 …”