Solid tumours of the epididymis report of two cases

Sworn, B. R.; Marshall, F. W.; Edwards, J. L.

doi:10.1002/bjs.18003313214

Cited by 12 publications

(2 citation statements)

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“…9 The extent of the smooth muscle component varies and can be so extensive that it overtakes and obscures the adenomatoid tumor, resulting in its misdiagnosis as either a leiomyoma or a malignant tumor infiltrating smooth muscle bundles. 20 First described in 1946, 7 the tumor remains a rarely diagnosed entity, with only 7 cases reported to date. This may reflect the truly infrequent nature of this entity or its frequent misdiagnosis as a leiomyoma due to the scant adenomatoid component being overrun by the smooth muscle component.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Epididymal leiomyomas, which arise from smooth muscle, are the second most common tumor of the epididymis in adults. 4–6 Leiomyoadenomatoid tumors of the epididymis, previously described as a “mixed tumor of the epididymis” by Sworn et al 7 and “adenomatoid leiomyoma” by Wilson, 8 were defined by Epstein 9 in 1992 to describe an adenomatoid tumor with a prominent smooth muscle component. Only 7 cases of leiomyoadenomatoid tumors have been reported to date in English literature.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors—A Report of two Cases

et al. 2022

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Leiomyoadenomatoid tumors of the epididymis are exceedingly rare biphasic tumors composed of an adenomatoid component in the form of gland-like structures lined by single flat or cuboidal cells admixed with smooth muscle. Radiological and gross findings cannot distinguish leiomyoadenomatoid tumors from the more common classic adenomatoid tumors or leiomyomas, and careful microscopic examination is critical in the identification of this esoteric variant. The histogenesis of this entity remains ambiguous. Common hypotheses include a collision tumor, a variant of an adenomatoid tumor with a smooth muscle component, or an adenomatoid tumor arising in the background of reactive smooth muscle hyperplasia. We present 2 cases of leiomyoadenomatoid tumors with diffuse nuclear WT1 positivity in both the adenomatoid and smooth muscle components, supporting the mesothelial origin of these tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors—A Report of two Cases

et al. 2022

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Local invasion in adenomatoid tumors

Miller

Lieberman

1968

Cancer

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Twelve adenomatoid tumors of the male genital tract are reported; three of them locally invaded the adjacent testis. These cases are compared with two previously reported instances of invasion. No evidence has been found to suggest that those tumors showing local invasion behave differently from the usual adenomatoid tumors. The presence of such invasion should be recognized as a problem in frozen section diagnosis. In view of these observations only local excision of the tumor appears to be indicated.

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Adenomatoid leiomyoma of the epididymis

Wilson¹

1949

Journal of British Surgery

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Solid tumours of the epididymis report of two cases

Cited by 12 publications

References 5 publications

Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors—A Report of two Cases

Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors—A Report of two Cases

Local invasion in adenomatoid tumors

Adenomatoid leiomyoma of the epididymis

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