Solid variant of papillary carcinoma thyroid in a child with no history of radiation exposure

Damle, Nishikant; Ramya, S.; Bal, Chandrasekhar; Durgapal, Prashant

doi:10.4103/0972-3919.106707

Cited by 14 publications

(16 citation statements)

References 7 publications

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“…Damie et al 8 reported a case of a 12-year-old girl with left cervical lymphadenopathy, in which differential diagnoses of poorly differentiated carcinoma, medullary carcinoma, anaplastic carcinoma and metastatic carcinoma of the thyroid were considered; however, finally it was confirmed solid variant of PTC metastases to left cervical lymph nodes. In that case, fine needle aspiration cytology (FNAC) suggested a differential of Hurthle cell neoplasm or medullary carcinoma of the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Solid variant of papillary thyroid carcinoma in a 14-year-old girl

et al. 2013

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Solid variant of papillary thyroid carcinoma (PTC) is a rare, poorly characterised variant and predominantly reported in children with a history of radiation exposure. This variant has a high propensity for extra-thyroidal extension and cervical lymph node metastases. A 14-year-old Malay girl who had no history of radiation exposure, presented with multiple cervical lymphadenopathy and it was clinically suspicious for tuberculosis or lymphoma. An incisional biopsy revealed a metastatic PTC. The patient underwent total thyroidectomy with bilateral lateral neck dissection and histopathology report was solid variant of PTC. Whole-body I131scan was performed which revealed an intense tracer uptake in the neck. She was planned for radioactive iodine ablation and now on regular follow-up for monitoring of possible tumour metastasis.

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Section: Discussionmentioning

confidence: 99%

Solid variant of papillary thyroid carcinoma in a 14-year-old girl

et al. 2013

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“…Conventionally, it has been associated with childhood presentation, prior radiation exposure, and a less favorable prognosis than cPTC [17, 18]. However, a few authors have reported these tumors to have age and prognosis comparable to cPTC and no association with radiation exposure [4, 5, 18]. All our patients were also adults, with a mean age of 43.9 years.…”

Section: Discussionmentioning

confidence: 96%

“…Only 3 studies detailing cytological features of this rare variant have been published [7, 12, 18]; the rest are case reports or lack detailed description [4, 5, 19-22]. We retrospectively evaluated aspiration smears of 9 SVPTC cases we came across over a period of 3 years and compared their various cytomorphological features with those of NIFTP/FVPTC, cPTC, and PDTC.…”

Section: Discussionmentioning

confidence: 99%

“…This variant is known to metastasize more frequently, with a less favorable prognosis as compared to the classical type [6]. However, it has a better outcome than poorly differentiated thyroid carcinoma (PDTC) [5, 7], with which it shows architectural overlap.…”

Section: Introductionmentioning

confidence: 99%

“…Solid/trabecular variant of PTC (SVPTC) is relatively rare, constituting 3% of all adult-onset PTCs [2]. Initially thought to occur preferentially in children, especially after radiation exposure, SVPTC has now been reported even in adults, irrespective of radiation history [3-5]. This variant is known to metastasize more frequently, with a less favorable prognosis as compared to the classical type [6].…”

Section: Introductionmentioning

confidence: 99%

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Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors

et al. 2018

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Objectives: Solid variant of papillary thyroid carcinoma (SVPTC) is rare, differing from classical PTC (cPTC) in architecture and outcome. We evaluated the cytomorphology of SVPTC cases to assess the feasibility of a preoperative diagnosis. Study Design: SVPTC cases were evaluated for architecture, nuclear features, and Bethesda category and were compared with noninvasive follicular thyroid neoplasm with papillary-like nuclear features/follicular variant of PTC (NIFTP/FVPTC), cPTC, and poorly differentiated thyroid carcinoma (PDTC). Results: Nine SVPTCs, 29 NIFTP/FVPTCs, 12 cPTCs, and 4 PDTCs were included. The predominant architecture in most SVPTCs was solid fragment, which is helpful in differentiating them from NIFTP/FVPTC (p < 0.001) and cPTC (p = 0.006) but not from PDTC. The presence of microfollicles led to misinterpretation as NIFTP/FVPTC/follicular neoplasm in 4 patients. All but 1 SVPTC showed diffuse nuclear features. Intranuclear pseudoinclusions (INIs) were seen in 67% of SVPTCs as compared to 83% of cPTCs, 14% of NIFTP/FVPTCs (p = 0.005), and none of PDTCs. SVPTC cases were commonly (78%) categorized as intermediate/suspicious. Conclusions: The presence of solid fragments and lack of true papillae are helpful in differentiating SVPTC from cPTC. Solid fragments, trabeculae, the extent of nuclear features, and INIs should be looked for in cases with prominent microfollicles for distinguishing SVPTC from NIFTP/FVPTC. None of the features were helpful in differentiating SVPTC from PDTC.

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Fine‐needle aspiration cytology of the solid variant of papillary thyroid carcinoma: A study of 13 cases with clinical, histologic, and ultrasound correlations

Giorgadze

Scognamiglio

Yang

2015

Cancer Cytopathology

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BACKGROUND:The solid variant of papillary thyroid carcinoma (SVPTC) comprises approximately 3% of thyroid cancers, and there are conflicting reports about its behavior in the literature. The cytology of SVPTC is limited to 3 single case reports, a review article, and a monograph. We present the first cytologic study of SVPTC. METHODS: Fine-needle aspiration smears obtained with ultrasound guidance from 13 patients with histologically pure SVPTC were reviewed, and the cytologic features recorded. Ultrasound images were retrieved from radiology and were correlated with low-power histology images. Intratumor vascularity on Doppler imaging was correlated with cellularity in cytology samples. RESULTS:Three cytomorphologic patterns of SVPTC were identified: cohesive, syncytial-type tissue fragments; microfollicles/trabeculae; and dyshesive single cells. All 3 SVPTCs in the first group were encapsulated without invasion. Two of 6 SVPTCs in the second group had a single lymph node metastasis; 4 were encapsulated, and 2 had pushing borders. Ultrasound images in the first and second SVPTC groups were similar, with the majority revealing a well defined, solid nodule with minimal intranodular vascularity. All 4 SVPTCs in the third group had infiltrative borders; and, with the exception of one 0.8-cm tumor, all had multiple lymph node metastases. Ultrasound in the third group revealed irregular borders. RET/PTC1 and RET/PTC3

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Solid variant of papillary carcinoma thyroid in a child with no history of radiation exposure

Cited by 14 publications

References 7 publications

Solid variant of papillary thyroid carcinoma in a 14-year-old girl

Solid variant of papillary thyroid carcinoma in a 14-year-old girl

Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors

Fine‐needle aspiration cytology of the solid variant of papillary thyroid carcinoma: A study of 13 cases with clinical, histologic, and ultrasound correlations

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