Solitary Bronchial Mucosal Neuroma

Solitary bronchial neuroma associated with asthma: chronic irritation pathogenesis?

“…It seems that the present mucosal neuroma originated from abnormal growth of the end portion of the vagus nerve, as Miura et al. 5 have stated. The presence of chronic irritation to the mucosa suggests one of the causes 7 .…”

“…Mucosal neuromas appear in the mucous membrane of the conjunctiva, lip, oral cavity, tongue and gastrointestinal canal in patients with MEN type 2B, and are regarded as constant components of MEN type 2B 2 . However, a solitary mucosal neuroma without MEN type 2B is remarkably rare, with only four cases, occurring in the conjunctiva, bronchi, tongue, and rectosigmoid colon, having been reported 3–6 …”

Solitary mucosal neuroma in the maxillary incisor gingival papilla without multiple endocrine neoplasia type 2B (MEN 2B): a case report and literature review

“…Twelve articles with MN cases without MEN 2B were reviewed [5][6][7][8][9][10][12][13][14][15][16][17]; all articles were published before December 2019. The epidemiology, clinical presentation, surgical treatment, and outcome of this sample population are described in Table 1.…”

“…MN of MEN 2B is always observed on the mucosal surfaces of the lips, tongue, eyelids, and intestines of patients [4], but rarely occur without the other abnormality about MEN 2B. MN without MEN 2B have been reported in the rectosigmoid colon [5], bronchi [6,7], conjunctiva [8], laryngeal [9,10,15], tongue [12][13][14][15], lip [13]and hard palate [16], but there has been no reported case in the gingiva to our knowledge.…”

“…Clinically, MN usually presents as a rm, slowly enlarging, small, circumscribed mass, which is painless in most cases [3,7,13,16], although it can frequently cause symptoms such as pain and paresthesia [5,6,9,10,15]. In the vast majority of cases, complete surgical excision is curative; however, recurrences have been reported in some cases [14,17].…”