Solitary fibrous tumour of the kidney with sarcomatous overgrowth . Case report and review of the literature

Magro, Gaetano; Emmanuele, Carmela; Lopes, Maria Manuel; Vallone, G; Greco, Paolo

doi:10.1111/j.1600-0463.2008.01012.x

Cited by 39 publications

(36 citation statements)

References 11 publications

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“…A limitation of our in vivo experiments is due to the intrinsic xenograft model characteristics, which specifically recapitulate the features of DSFT. In fact, SFT is a disease characterized by a broad spectrum of malignancy (1,(25)(26)(27) and DFST represent a particular subset among different SFT subtypes, though it is probably more frequent than believed in advanced SFT series. Thus, our preclinical findings need to be confirmed in so-called, less aggressive "malignant" SFT.…”

Section: Discussionmentioning

confidence: 99%

Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

Stacchiotti

Tortoreto

Bozzi

et al. 2013

Clinical Cancer Research

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Purpose: To explore the value of triazines in solitary fibrous tumor (SFT). Experimental Design: We retrospectively reviewed 8 cases of patients with SFT treated with dacarbazine (1,200 mg/m 2 every 3 weeks) as from January 2012. Then, we studied a dedifferentiated-SFT subcutaneously xenotransplanted into severe combined immunodeficient (SCID) mice. Dacarbazine, temozolomide, sunitinib, bevacizumab, and pazopanib were administered at their reported optimal doses for the mouse model when mean tumor volume (TV) was about 80 mm 3 ; each experimental groups included 6 mice. Drug activity was assessed as tumor volume inhibition percentage (TVI%). Dacarbazine was tested according to two different schedules of administration. One hunded twenty days after treatment interruption, mouse tumor samples were analyzed.Results: Among the eight patients treated with dacarbazine, best response evaluation criteria in solid tumors responses (RECIST) were three partial responses, 4 stable disease, 1 progression. Two responsive patients had paraneoplastic hypoglycemia that disappeared after 10 days from starting dacarbazine. In the dedifferentiated-SFT xenograft model, dacarbazine and temozolomide showed the highest antitumor activity (about 95% TVI), confirmed pathologically. Sunitinib and pazopanib were only marginally active (52% and 41% TVI, respectively), whereas bevacizumab caused a 78% TVI. No tumor regrowth was observed up to 100 days from end of treatment with temozolomide and dacarbazine, whereas secondary progression followed sunitinib, pazopanib, and bevacizumab interruption.Conclusions: Dacarbazine as single agent has antitumor activity in SFT. Our preclinical results suggest a cytotoxic effect of temozolomide and dacarbazine, as compared with a cytostatic role for sunitinib, pazopanib, and bevacizumab. A phase II study on dacarbazine in advanced SFT is planned.

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Section: Discussionmentioning

confidence: 99%

Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

Stacchiotti

Tortoreto

Bozzi

et al. 2013

Clinical Cancer Research

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“…SFT reveals diffusely positive reactivity for CD34 which is now considered to be a characteristic marker of SFT [9]. Other positive markers found frequently in SFT include Bcl-2 and CD99 [10]. On the contrary, SFT in general shows negative reactivity for cytokeratin, alpha-SMA, S-100, CD31 and c-kit.…”

Section: Discussionmentioning

confidence: 99%

“…and Fine et al . have reported two cases of malignant renal SFTs developing via dedifferentiation or sarcomatous overgrowth from a pre-existing benign SFT [10,14]. Hsieh et al .…”

Section: Discussionmentioning

confidence: 99%

A huge malignant solitary fibrous tumor of kidney: case report and review of the literature

Wang

Liao

et al. 2014

Diagn Pathol

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Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1603694556107408.Solitary fibrous tumor (SFT) is a spindle cell neoplasm that rarely occurs in the kidney. Malignant SFT of the kidney is particularly rare. Here, we report a 66-year old woman with a right flank mass that has been proved clinically and radiographically. Grossly, the largest diameter of the mass were measured up to 23 cm, was poorly circumscribed. Approximately 80% of the neoplasm consisted of hyperchromatic and pleomorphic spindled cells surrounding staghornlike blood vessels. Tumor cells frequently had mitoses and necrosis. However, the remainder of the mass was composed of haphazard, storiform or short fascicular arrangements of spindle cells in a loose myxoid to fibrous stroma. Immunohistochemically, we observed diffusely strong CD34 staining and an 85% Ki-67 proliferative index. The tumor partly showed negative CD34 and a 20% proliferative index. To our knowledge, this is the largest malignant renal SFT in the reported literatures and shows an obviously high proliferative index.

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“…Malignant behaviors such as metastasis and recurrence are observed in 10% of extrapleural tumors and 10%–15% of intrapleural tumors [12]. Malignant behavior has been reported in a limited number of cases in the literature [13–15]. A careful and adequate resection is the mainstay of therapy of renal SFT.…”

Section: Discussionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Kidney: A Case Report

Demirtaş

Sabur

Akgün

et al. 2013

Case Reports in Urology

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Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11 cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. Despite repeated stainings with vimentin, no clear tumor evaluation could be made due to artifacts. The tumor was negative with Bcl-2, desmin, HMB-45, S100, FVIII, and CD31. Histopathological and molecular studies made the diagnosis of a solitary fibrous tumor. The patient is now currently free of disease at the 26th month of followup.

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Solitary fibrous tumour of the kidney with sarcomatous overgrowth . Case report and review of the literature

Cited by 39 publications

References 11 publications

Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

A huge malignant solitary fibrous tumor of kidney: case report and review of the literature

Solitary Fibrous Tumor of the Kidney: A Case Report

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